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A Quest for the Holy Grail of Cancer Targets
Danielle Gerhard, PhD | Mar 14, 2024 | 5 min read
Christopher Klebanoff hopes that his search for a small fraction of cancer-specific antigens will have a big impact on cancer cell therapies.
3D Rendering of Molecular Interaction in CAR Chimeric Antigen Receptor
Next-generation CAR and TCR Cancer Therapies
Danielle Gerhard, PhD | Mar 15, 2024 | 10+ min read
From smart receptors to novel biologics, scientists plan to overcome the challenges of treating solid tumors.
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Artificial Neural Networks: Learning by Doing
Shelby Bradford, PhD | Mar 1, 2024 | 8 min read
Designed to mimic the brain itself, artificial neural networks use mathematical equations to identify and predict patterns in datasets and images.
One Protein to Rule Them All
Shelby Bradford, PhD | Feb 28, 2024 | 10+ min read
p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.
All-nighters Sometimes Combat Depression
Hannah Thomasy, PhD | Jan 5, 2024 | 3 min read
Dopamine pathways play a key role in the surprising effects of sleep deprivation on mood.
Addressing Power and Pitfalls in Machine Learning Neoantigen Prediction
Deanna MacNeil, PhD | Dec 11, 2023 | 4 min read
Researchers honed prediction models and datasets to unlock the potential of deep neural networks in biological applications while avoiding bias.
On display
Jonathan Weitzman(jonathanweitzman@hotmail.com) | Mar 19, 2001 | 1 min read
Molecular reagents that bind to specific proteins with high affinity are valuable tools in the endeavour to understand protein function. In the Early Edition of Proceedings of the National Academy of Science, Wilson et al. describe how a method based on mRNA display can be used to identify ligands with higher affinity than those selected using the phage display technique. The new technique generates polypeptides that are linked via a puromycin moiety to their encoding mRNAs. Wilson et al. demons
Move Over, Proteins! Exploring Lipids in Adaptive Immunity
Kamal Nahas, PhD | Nov 27, 2023 | 5 min read
New research revealed hundreds of lipid antigens that may be recognized by adaptive immune T cells.
Phage Display Alternative: Invitrogen's Yeast Display Vectors
Laura Defrancesco | May 9, 1999 | 3 min read
Aga2-fusion protein binding to yeast cell by Aga1. Image provided by Invitrogen. Phage display systems, reviewed in a recent issue of The Scientist,1 have proven enormously useful for the detection of protein-ligand interactions, as well as for the selection of variants with altered binding characteristics. However, limiting the utility of phage display systems are so-called expression biases against certain eukaryotic proteins, as well as the distinctly different protein processing mechanisms
A triangular sign affixed to a tree displaying the silhouette of a tick.
Newly Developed mRNA Vaccine Protects Against Lyme Disease
Charlene Lancaster, PhD | Nov 13, 2023 | 5 min read
Leveraging the same mRNA platform used for COVID-19 vaccines, researchers generated a vaccine that prevents mice from acquiring Lyme disease.

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