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1: J Theor Biol. 2003 Nov 21;225(2):147-51.
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Does tumor growth follow a "universal law"?

Guiot C, Degiorgis PG, Delsanto PP, Gabriele P, Deisboeck TS.

Dip. Neuroscience, Universita di Torino, C. Raffaello 30, 10125, Torino, Italy. caterina.guiot@unito.it

A general model for the ontogenetic growth of living organisms has been recently proposed. Here we investigate the extension of this model to the growth of solid malignant tumors. A variety of in vitro and in vivo data are analysed and compared with the prediction of a "universal" law, relating properly rescaled tumor masses and tumor growth times. The results support the notion that tumor growth follows such a universal law. Several important implications of this finding are discussed, including its relevance for tumor metastasis and recurrence, cell turnover rates, angiogenesis and invasion.

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PMID: 14575649 [PubMed - indexed for MEDLINE]