Pain
Volume 19 | Supplement 1 | March 28, 2005
The Scientist

is pleased to present this special supplement on the medical problem of pain and how biomedical research is addressing the needs of millions suffering from it.
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More about Johnson & Johnson Pharmaceutical Research & Development
DEALING WITH PAIN
We are now halfway through the Decade of Pain Control and Relief. How far have we come?
By Brendan A. Maher
and Richard Gallagher
THE ESSENCE OF PAIN
SKETCH OF THE SUBJECTIVE
How do you study that which words fail to describe?
By Ricki Lewis
Timeline:
A History of Analgesia and Anesthesia (flash required)
Life without Pain
The child's parents first realized something was wrong when their 4-month-old developed severe teething sores.
Animal Models of Pain
Non-human animals are good - but hardly perfect - models for pain research.
REDEFINING THE SEARCH
FOR THE MAGIC BULLET
Rather than a single pain treatment, effective relief may require an arsenal, says a world-renowned pain researcher
By Ronald Dubner
BELIEF AND NARRATIVE
An understanding of pain, bereft of its cultural dimensions, is woefully incomplete
By David B. Morris
ATTUNING TO A LIFE IN PAIN
How a chronic syndrome altered a life and shaped a mission
By Laura M. Hrastar
THE BASICS OF A PAIN PATHWAY
SIGNALS FROM THE FRONTLINES
Researchers grapple with the intricacy of pain perception at the peripheral level
By Megan M. Stephan
How Hot Peppers Helped David Julius Make the TRP Channel Connection
Mechanosensation Solved?
GATEWAYS TO PATHOLOGICAL PAIN
Signal transduction and the immune system
By Jill U. Adams
From Nerves to Immunity
How a chemotherapy side effect led to an important discovery
Pain Hypersensitivity and Morphine Tolerance: Shared Mechanisms?
THE INTERPRETER
Brain imaging works to capture the many natures of the pain experience
By Eugene Russo
Approaching Pain's Layers Through Hypnosis
UPS AND DOWNS OF PAIN THERAPY
THE QUEST FOR PAIN RELIEF
How much have we improved on the past?
By Stephen Pincock
A gallery of pain medication advertisements and labels from the John C. Liebeskind History of Pain Collection
An Onus on Conus
A venomous sea snail offers a
pain-fighting peptide.
By David Secko
Nicotine to Snuff Out Pain
By Tabitha Powledge
Pot for Pain
By Tabitha Powledge
Tricylics: The Complex Analgesics
By Mark Greener
Gabapentin Marches Toward Mechanism
By Jack Lucentini
A DELICATE BALANCE
Opiates are more common, but more controversial than ever
By Anne Harding
COX-2 STUDIES STYMIED
The fallout from Vioxx's withdrawal has left some researchers asking where to go from here
By Beth Piskora
THE COX-3 IDENTITY CRISIS
Researchers struggle to place a cyclooxygenase splice variant in context
By Mark Greener
INSTITUTIONAL GAINS ON PAIN
McGill University builds on its legacy
By Steve Mirsky

ADVISORS

While responsibility for the content rests solely with the editors, we gratefully acknowledge the following group of advisors, who provided much advice and support on this supplement

James Campbell
Professor of Neurosurgery
Johns Hopkins University

Alan Cowan
Professor of Pharmacology
Temple University

Christopher M. Flores
Analgesics Team Leader,
Drug Discovery
Johnson & Johnson PRD

Juergen Haeussler
VP, Associate Therapeutic
Area Head Pain
Johnson & Johnson PRD

Scott Reines
Senior Vice President,
CNS/Pain Center of Excellence
Johnson & Johnson PRD

Michael W. Salter
Director,
Center for the Study of Pain
University of Toronto

Gary R. Strichartz
Professor of Anesthesia
(Pharmacology)
Harvard Medical School

Michael R. Vasko
Paul Stark Professor of Pharmacology Chair,
Department of Pharmacology
and Toxicology
Indiana University

Jon-Kar Zubieta
Associate Professor and
Associate Research Professor
University of Michigan

Special thanks to Seema Kumar, Vice President of Global Pharmaceutical R&D Communications at Johnson & Johnson, for her vision, support, and passion throughout this project.