Trials of the heart
Dozens of human trials have already begun to assess the efficacy of adult stem cells in treating heart disease. This listing shows details for several ongoing and recently terminated trials. You can sort the listing using the controls at top and click through the trial name for more information courtesy of the National Library of Medicine.
| Study Name | Phase | Status | Condition | Intervention | Design | Size | Sponsor |
|---|---|---|---|---|---|---|---|
| ACT34-CMI Adult Autologous CD34+ Stem Cells | II | R | Myocardial Ischemia | Stem Cell Injection | T, R, DB, PC, PA, SE | 150 | Baxter Healthcare Corporation |
| Amorcyte Myocardial Repair Study (AMRS) | I | R | Myocardial Infarction Coronary Artery Disease | Intracoronary Infusion of Autologous Bone Marrow Derived CD34+ Stem Cell Product | T, R, OL, AC, FA, SE | 40 | Emory University |
| A Phase I - II Safety Study of Filgrastim (neupogen) to Improve Left Ventricular Function after Severe Acute Myocardial Infarction | I/II | R | Acute Myocardial Infarction | G-CSF (Neupogen) | T, R, SB, PC, PA | 9 | Cleveland Clinic |
| Autologous Cultured Myoblasts (BioWhittaker) Transplanted Via Myocardial Injection | I | NYR | Congestive Heart Failure Coronary Artery Disease Myocardial Infarction | MyoCell™ Autologous Myoblasts | T, NR, OL, HC, FA, SS | 15 | Bioheart, Inc |
| Autologous Progenitor Cell Therapy for Congestive Heart Failure | I | R | Congestive Heart Failure | Injection of Bone Marrow Cells in the Heart | T, NR, OL, AC, SG, SS | 10 | University of Pittsburgh |
| Autologous Progenitor Cell Therapy for Congestive Heart Failure Patients Undergoing Coronary Artery Bypass Grafting (CABG) Surgery | I | R | Congestive Heart Failure | Injection of Bone Marrow Progenitor Cells into the Heart | T, R, DB, PC, FA, SS | 75 | University of Pittsburgh |
| Autologous Stem Cells for Cardiac Angiogenesis | I | R | Ischemic Cardiomyopathy | Intramyocardial Injection of Stem Cells Via Noga Mapping | T, R, SB, PC, CA, SE | 30 | Texas Heart Institute |
| Autologous Stem Cell Transplantation in Acute Myocardial Infarction (ASTAMI) | II | NLR | Acute Anterior Wall Myocardial Infarction | Intracoronary Autologous Stem Cell Transplantation | T, R, SB, AC, PA, SE | 100 | Rikshospitalet-Radiumhospitalet HF, Norway |
| Bone Marrow-derived Stem Cell Transfer in Acute Mycardial Infarctions | II | C | Myocardial Infarction | Bone Marrow-derived Stem Cell Transfer | EC, R, DB, PC, SG, ES | 68 | University Hospital Gasthuisberg, Belgium |
| Bone Marrow in Acute Myocaridal Infarction (BONAMI) | II | R | Acute and Severe Myocardial Infarction | Intracoronary Injection of Autologous Bone Marrow Monomuclear Cells | T, R, OL, AC, PA | 100 | Nantes University Hospital, France |
| Bone Marrow Stem Cell Infusion Following a Heart Attack | I | R | Acute Myocardial Infarction | Autologous, Unfractionated Bone Marrow Mononuclear Cells | T, R, DB, PC, CA, SE | 60 | Minneapolis Heart Institute Foundation |
| Bone Marrow Stem Cell Mobilisation Therapy for Acute Myocardial Infarction (REVIVAL-2) | IV | C | Myocardial Infarction | G-CSF (Neupogen) | T, R, DB, PC, PA, ES | 114 | Deutsches Herzzentrum Muenchen, Germany |
| Bone Marrow Transfer to Enhance ST-Elevation Infarct Regeneration (BOOST) | I | C | Coronary Artery Disease | Intracoronary Bone Marrow Cell Transfer | T, R, OL, AC, PA, SE | 60 | Hannover Medical School, Germany |
| Cell Therapy for Coronary Heart Disease | II | T | Coronary Artery Disease | Intracoronary Infusion of Progenitor Cells | T, R, OL, AC, CA, SE | 75 | Johann Wolfgang Goethe University Hospitals, Germany |
| Cell Therapy in Chagas Cardiomyopathy | III | R | Chagas Cardiomyopathy | Stem Cell, Filgrastim (G-CSF) | T, R, DB, PC, PA, SE | 300 | Ministry of Health, Brazil |
| Cell Therapy in Dilated Cardiomyopathy | III | Dilated Cardiomyopathy | Stem Cell | T, R, DB, PC, PA, SE | 300 | Ministry of Health, Brazil | |
| Cellwave Study: Combined Extracorporal Shock Wave Therapy and Intracoronary Cell Therapy in Chronic Ischemic Myocardium | I/II | R | Congestive Heart Failure | Extracorporal Shock Wave Therapy and Introcoronary Cell Therapy | T, R, DB, PC, PA, SE | 100 | Johann Wolfgang Goethe University Hospitals, Germany |
| Effect of Nitric Oxide Donor on Endothelial Progenitor Cells in Patients with Coronary Artery Disease | II | C | Coronary Artery Disease | Behavior | T, SE | 30 | NHLBI |
| Endothelial Progenitor Cells and Nitric Oxide in Cardiac Rehabilitation Program Participants | R | Coronary Artery Disease | Behavior | NH | 45 | NHLBI | |
| Endothelial Progenitor Cells and Risk Factors for Coronary Artery Disease | C | Coronary Arteriosclerosis | Behavior | NH | 120 | NHLBI | |
| Intracoronary Progenitor Cells in Acute Myocardial Infarction: REPAIR-AMI | III | T | Myocardial Infarction | Intracoronary Infusion of Enriched Bone Marrow-derived Progenitor Cells | T, R, DB, PC, PA, ES | 200 | Johann Wolfgang Goethe University Hospitals, Germany |
| Intramyocardial Injection of Autologous Aldehyde Dehydrogenase-bright Stem Cells for Therapeutic Angiogenesis | I | R | Coronary Artery Disease | Stem Cell Injection Under Electromechanical Guidance | T, R, DB, PC, CA, SE | 60 | Texas Heart Institute |
| Myocardial Regeneration and Angiogenesis in Myocardial Infarction with G-CSF and Intracoronary Stem Cell Infusion (MAGIC Cell-2) | II | T | Myocardial Infarction | G-CSF, Collection, and Intracoronary Infusion of Mobilized Cells | T, R, OL, PC, PA, SE | 20 | Seoul National University, Korea |
| Myocardial Regeneration and Angiogenesis in Myocardial Infarction with G-CSF and Intracoronary Stem Cell Infusion-3-DES (MAGIC Cell-3-DES) | II | C | Myocardial Infarction | G-CSF, Collection, and Intracoronary Infusion of Mobilized Cells | T, R, OL, PC, PA, SE | 100 | Seoul National University, Korea |
| MYOHEART™ (Myogenesis Heart Efficiency and Regeneration Trial) | I | R | Congestive Heart Failure Coronary Artery Disease Myocardial Infarction | MyoCell™ Device: MyoCath™ | T, NR, OL, HC, SG, SE | 20 | Bioheart, Inc |
| Progenitor Cell Therapy in Dilative Cardiomyopathy | I/II | R | Heart Failure, Congestive Cardiomyopathy, Dilated Stem Cell Transplantation | Intracoronary Infusion of BMC | T, R, OL, AC, SG, SE | 30 | Johann Wolfgang Goethe University Hospitals, Germany |
| Safety Study of Adult Mesenchymal Stem Cells to Treat Acute Myocardial Infarction | I | NLR | Myocardial Infarction | Provacel: Ex-vivo Cultured Adult Human Mesenchymal Stem Cells | T, R, DB, PC, PA, SS | 48 | Osiris Therapeutics |
| Stem Cell Mobilization and VEGF Gene Transfer for Heart Failure | I | R | Ischemic Congestive Heart Failure | Gene Transfer: Vascular Endothelial Growth Factor (VEGF1) | NR, OL, SG | 12 | Caritas St. Elizabeth's Medical Center of Boston |
| Stem Cell Mobilization to Treat Chest Pain and Shortness of Breath in Patients with Coronary Artery Disease | II | C | Coronary Artery Disease | G-CSF | T, SE | 35 | NHLBI |
| Stem Cells in Myocardial Infarction | II | C | Acute Myocardial Infarction | G-CSF (Neupogen) | EC, R, DB, PC, PA, SE | 78 | Rigshospitalet, Denmark |
| Stem Cell Study for Patients with Heart Disease | I | NLR | Chest Pain, Myocardial Ischemia Heart Disease Coronary Arterial Disease, Angina | Autologous Peripheral Blood CD34+ Cells | T, R, DB, PC, SE | 24 | Caritas St. Elizabeth's Medical Center of Boston |
| Stem Cell Study for Patients with Heart Disease | I | R | Myocardial Ischemia Heart Failure Congestive Heart Failure Cardiovascular Disease Low Ejection Fraction | Autologous Stem Cells | T, R, DB, PC, CA, SE | Caritas St. Elizabeth's Medical Center of Boston | |
| Stem Cell Study for Patients with Heart Disease | I/II | R | Chest Pain, Chronic Myocardial Ischemia, Coronary Artery Disease, Angina Myocardial Infarction | Autologous Peripheral Blood CD34+ Cells | T, NR, OL, SG, SE | 10 | Translational Research Informatics Center, Japan |
| Stem Cell Therapy for Vasculogenesis in Patients with Severe Myocardial Ischemia | I/II | NYR | Myocardial Ischemia, Coronary Heart Disease | Mesenchymal Stem Cells | T, NR, OL, AC, SG, SE | 40 | Rigshospitalet, Denmark |
| Stem Cell Therapy in Chronic Ischemic Heart Failure | II | R | Myocardial Ischemia Congestive Heart Failure, Bone Marrow Transplantation | Bone Marrow Transplantation | T, NR, OL, SG, SE | 35 | Odense University Hospital, Denmark |
| Stem Cell Therapy to Improve Myocardial Function in Patients with Acute Myocardial Infarction | R | Myocardial Infarction | Autologous Bone Marrow-derived Stem Cells | T, R, OL, AC, PA, SE | 200 | Silesian School of Medicine, Poland | |
| Study on the Efficacy and Mechanism of Cardiac Rehabilitation for Stem Cell Mobilization and Heart Failure Improvement | I | R | Myocardial Infarction | Behavior: Cardiac Rehabilitation | T, R, OL, AC, PA, SE | 50 | National Taiwan University Hospital |
| Study to Examine the Safety and Effectiveness of Implanted Skeletal Muscle Cells (Cells Removed from the Thigh Muscle) into Scarred Areas of Heart Muscle after Heart Attack. | II | Sus | Ischemic Heart Failure Ischemic Heart Disease Ischemic Cardiomyopathy | Cellular Therapy (Cultured Autologous Skeletal Myoblast Transplantation) | T, R, DB, PC, PA, SE | Genzyme | |
| The Effect of Exercise on Stem Cell Mobilization and Heart Function in Patients Undergoing Cardiac Rehabilitation | C | Coronary Arteriosclerosis | Behavior | NH | 50 | NHLBI | |
| The Effect of Mobilized Stem Cell By G-CSF and VEGF Gene Therapy in Patients with Stable Severe Angina Pectoris | I/II | C | Ischemic Heart Disease | Gene Transfer: VEGF-A165 Plasmid | T, NR, OL, PC, PA, SE | 48 | Rigshospitalet, Denmark |
| The Effects of External Counter Pulsation Therapy on Circulating Endothelial Progenitor Cells | C | Coronary Artery Disease | External Counter Pulsation Therapy | T, NR, OL, AC, CA | 25 | Sheba Medical Center, Isreal | |
| Treatment of Myocardial Infarction with Bone Marrow Derived Stem Cells | I | NYR | Acute Myocardial Infarction | Coronary Catherization and Stem Cell Infusion | EC, NR, OL, HC, SG, SS | 10 | Odense University Hospital, Denmark |
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