CONTENTS

November 2006

GAIL DUTTON reports from San Francisco on how infected nonprogressors – also known as elite controllers – are providing clues to the control, and potentially the eradication, of HIV.

Podcast: Resisting HIV: The Elite Controllers Feature contributor Gail Dutton talks with Steven Deeks about the rare and remarkable patients able to fight HIV.

RELATED:

Jeff Getty: Lessons in desperate measures
How a risky experiment led to a new understanding of HIV

25 Years with HIV

HIV Shows Itself
A 1981 report in the MMWR marks the beginning

The Impact of HIV
Its progressions, 1981-2006 and beyond

Why Monkeys Block HIV
Old world monkeys don't get infected, even though it enters their cells.

EMANUEL PETRICOIN and LANCE LIOTTA describe how their methods for discovery could solve the seeming end to the pipeline of disease detection biomarkers

Podcast: Biomarkers in the blood
Lance Liotta and Emanuel Petricoin discuss the promise and challenges of developing proteomic technologies for clinical diagnostics.


Proteomics: Promise and Problems
Such early disease detection doesn’t always mean longer life, write JENNIFER MILLER and BARNETT KRAMER.

RELATED:

INFOGRAPHIC: The Peptidome Hypothesis
What does a disease signature look like in the blood?

Serum Proteomics Scrutinized
SELDI-TOF still struggles to prove its worth as a clinical diagnostic tool

Rethinking Clinical Proteomics
After setback, biomarker researchers continue to debate the use of mass spectrometry in diagnostics

Toward a Global Proteome
HUPO makes public/private collaboration its priority

Software Zeroes In on Ovarian Cancer
A proteomic fingerprint with unprecedented diagnostic accuracy becomes a new kind of disease biomarker

Challenges to your business – both daily and long-term competitiveness – lurk in surprising places. BRUCE BELZAK explains how to protect your company.

Case study: A medical device component manufacturer faces nervous senior executives

RELATED:

Case study: What happens when a fire strikes your production facility?

Four ways to save money – and your business

Five Things Not to Forget When Forecasting
Forecast models can become complex, but the principles for gathering and vetting data for good predictions should remain basic.

Compensation continues to soar as the demand for highly skilled professionals heats up. How does your pay rate?
BY KAREN PALLARITO


Salary Map: Salaries and costs of living in 19 US metropolitan areas


Salary Charts:Salary by job activity, type of research, age, and job title


More salary surveys from The Scientist archive


RELATED:

Salary by Job Title

Salary by Area of Specialization

Salary by Gender

Salary by Ethnicity

Salary by Highest Degree Earned

The 2005 Life Sciences Salary Survey
Salaries were up, particularly in certain regions and in particular specialties. Where did you fit in?

Women Still Paid Less
In 2005, the year that Harvard's president questioned the ability of women to do science, women came up short

The 2004 Life Sciences Salary Survey
A leveling off in compensation was the trend for US researchers in 2004

This issue’s contributors

Mail

Are we training too many scientists? And intelligent lab design.

EDITORIAL

End this Stem Cell Racket: Once the Bush Administration policy is corrected, there’s another problem that’s at least as large.
RICHARD GALLAGHER

White Paper

The New Federalism in Life Sciences Policy: What states and the Federal government should do to ensure progress in the life sciences.
MELVIN L. BILLINGSLEY and MICHELE M. WASHKO

COLUMNS

Working With Stem Cells? Pay Up. What the Wisconsin patent stranglehold means for researchers
GLENN MCGEE

 

Saving Bison, Losing Tigers: Wildlife conservation, anthrax, and poaching.
>JACK WOODALL

The Agenda

Notebook

Scientists under the microscope; The cancer-fighting teen; Snyder, sludge fighter; Making science fresh; Arabadopsis in space

Foundations

The Discovery of Estrogen Receptor Beta

Profiles

The Fast Track to Success: Laura Landweber was 33 when she received tenure at Princeton. Oxytricha, beware: She still has a lot of science ahead of her.

Scientist to Watch

Sohyun Ahn: Thinking Things Through

The Literature

Hot Paper: On the Trail of a Point Mutation
The discovery of a blood-cancer gene raises tantalizing questions

SNPs for Diabetes: Hot Paper in human genetics

Tetramer model trashed: Hot Paper in histone biology

Why hormone therapy fails: Hot Paper in cancer biology

Papers to Watch

New technique IDs odor-related neurons

How to predict epistatic gene interactions

Lab Tools

Lab Equipment You Need - Sort of: Musings on a product catalog

Six Things You Won’t Find in the MAQC: The MicroArray Quality Control consortium released gigabytes of data and two exhaustively characterized RNAs, but little actionable guidance
JEFFREY PERKEL

BioBusiness

Getting Your Gates: How one company used the growing nonprofit funding pot to jump-start its development program, and how you can do the same

CAREERS

Classified Ad Confidential: To attract not just more candidates but the right ones, pay attention to the basics and follow these tips.

Making better leaders out of alpha males and females

Third-tier grads do better than mid-ranked grads

Russian scientists test new merit bonus system