CONTENTS

December 2006

Nicholas White and François Nosten have shown that drugs in combination with artemisinin are 90% effective at fighting the scourge of the world. So why isn't everyone using it? MERRILL GOOZNER travels to Thailand and China to watch Nosten and White at work.

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A military outbreak spurs research

The first 13-year-old patient

Slideshow: photos from Goozner's travels, including a stop at a clinic conducting artemisinin trials

MIT's ALEXANDER RICH, who discovered RNA hybridization in 1956, describes what it has meant to biology. It all started, he says, when he used to walk into the basement of the Cal Tech chemistry department.

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An interactive look at original documents with commentary:

The discovery of the dsRNA helix, 1956

Predictions on the regulatory potential of dsRNA, 1961

RNA Timeline: A History in Hybridization and Structure

Gerd Maul, an unlikely vaccinologist, fights an unlikely foe. Join ALAN DOVE as he visits Maul's lab to find out why the scientist is trying to come up with a vaccine for a virus most people caught years ago and few will likely ever notice.


Podcast: A vaccine for cytomegalovirus
Progress toward combating a rare but costly disease

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Developing a hybrid CMV vaccine

An economic boost for an unlikely target

Two sides or more: from scientist to sculptor

Slideshow: the artwork of Gerd Maul

As the agency celebrates its 100th anniversary, what's next? TED AGRES finds out what Congress has in store.

RELATED:

Just another day at the office?
KEN KAITIN and CHRISTOPHER-PAUL MILNE present their wish list for the FDA

Timeline: 100 years of FDA history

 

This issue’s contributors

Mail

Is Bush science's nemesis? Bird flu: Preventing paranoia

EDITORIAL

Just One Vote: The new US political landscape might be just different enough to boost stem cell research.
RICHARD GALLAGHER

White Paper

How to Treat Premature Infants: A Nuffield Council Working Party takes on ethical issues in neonatal critical care.
MARGARET BRAZIER

COLUMNS

Want Fish? Ethics First, Please: Why we should worry about the upcoming fish apocalypse.
GLENN MCGEE

Intelligent Design: The Clincher. A butterfly explodes the theory.
JACK WOODALL

The Agenda

Notebook

The frog robot condom; Filter my blood, please; When biodiversity makes you sick; Use the force, bacteria; From chemist to cook

Foundations

An automated PCR prototype, circa 1985

Profiles

Physics Meets the Brain: How Terry Sejnowski went from a grad student in theoretical physics to computational neuroscience's White Knight.
KAREN HOPKIN

Scientist to Watch: Victoria Orphan
 

BioBusiness Profile: Mersana CEO Julie Olsen. What happens when someone leaves cutting deals at pharma giant Pfizer for the life at a start up?

The Literature

Hot Paper: A double life for mTOR, the target of rapamycin, muddies its role in cancer.

Astrocytes and glutamate

Leads on the obesity-diabetes link

Papers to Watch

A candidate for transduction in hearing

JNK2 and cJun activation

How trypanosomes move into the brain

Lab Tools

Who wants the X Prize for human genome sequencing?
JEFFREY PERKEL

How to troubleshoot quantitative Q-PCR

How It Works: Q-PCR

CAREERS

What will your 2006 bonus look like?