CONTENTS

August 2006


FEATURES
In 2004, close to one in five extramural NIH dollars went to only 10 of the 3,000 institutions that received grants. Five US states get almost half of all funding. What about everyone else?
By Alison McCook
How to get to the top
Principal investigators on last year's list of the 20 biggest grants offer advice about how to get where they are.
Here are examples of some notable papers that have come out of the University of North Dakota and the University of South Dakota in recent years. Citations are as of July 18, 2006.
How an apolipoprotein E isoform wreaks havoc in the brain, and what we might be able to do about it.
By Robert Mahley and Yadong Huang
Results from the first round of controlled human stem cell trials for heart disease are in. What have we learned?
By Kenneth Chien
Delivering on the Dream
Some of the cell types and delivery methods that are being investigated for the treatment of heart disease both in and out of the clinic.
An interactive listing of recent clinical trials treating heart disease with adult stem cell therapies
See our August 9 podcast to hear Kenneth Chien assess the clinical progress of adult human stem cells in cardiac care
With billions being spent on new labs and renovations, do shinier labs really make for better science?
By Ishani Ganguli
Anatomy of an energy-sustainable lab renovation
 
ALSO THIS MONTH

SCIENCE IN THE HEARTLAND

The East and West coast powerhouses aren't the only places where good science flourishes.
By Richard Gallagher

MAIL

Restoring natural capital; Rafts and rubbish; Upgrading to TIRF; Cockroaches everywhere

THE AGENDA

Old-time drug discovery; Building ecocities; Controlling mercury; Conscious of Consciousness

IRAQ'S MARSHES RETURN

By Anne Harding

THE MALARIA HUT

By Silvia Sanides

TASERED PIGS

By David Secko

DOG CHASES WHALE SCAT

By Kirsten Weir

SCIENTISTS, MEET POLITICIANS

By Stephen Pincock

THE NEED FOR BIODEFENSE STANDARDS

Seven questions for the industry to answer as it moves forward
By Scott Jenkins and Joseph Perrone

A BLOODY MESS

Emergency research raises the question: Can trials without consent work?
By Glenn McGee

THE SHAPE OF ARMAGEDDON

Sure, the world will end. What will rise up to take the place of human civilization?
By Jack Woodall

STOPPING THE CYCLE

Stefan Kappe's insights into parasite development have already led to a live malaria vaccine for mice.
By Melissa Lee Philips

LONG LIFE AND
FORKHEAD DEACETYLATION

Race to understand mammalian longevity marries SIRT1 to FOXO
By David Secko

ERROR PRONE AGING

By David Secko

HOW MONKEYS BLOCK HIV

By Charles Q. Choi

CANDIDA CHALLENGES

By Chandra Shekhar

PAPERS TO WATCH

 

BIGHORNS OUTBRED

 

BUILDING THE SYNAPSE

 

SCIENTIST TO WATCH

Neil Kelleher:
Thinking big then doing it
By Jeffrey M. Perkel

THE SCIENTIFIC DO-OVER

What would you do if you could apply modern technologies to yesterday's scientific questions?
By Jeffrey M. Perkel

VIRAL VECTORS ON THE WEB

Manufacturer's online tool lets you custom design a lentiviral vector
By Chandra Shekhar

FACELIFT FOR LIPOFECTAMINE

New reagents designed to make liposomal transfection more versatile and efficient
By Chandra Shekhar

MICROARRAYS MEASURE UP WELL

Surprise: study finds good cross-platform comparability
By Chandra Shekhar

RNA DYES FOR LIFE

New stain may work where others don't
By Sarah Rothman

SIT ON THE WEB, DESIGN A CHAIR

Configure your own lab chair online
By Chandra Shekhar

HOW IT WORKS

Bead-based multiplexing
By Jeffrey M. Perkel

THE BEST OF TIMES,
THE WORST OF TIMES

Changes in investment strategies in the midst of a volatile market point the way towards stability.
By Paul J. Pospisil

ANTIGENICS: DOWN, BUT NOT OUT?

Confronted with unfavorable clinical data, CEO Garo Armen is working to pull Antigenics out of its downward spin
By Aaron J. Bouchie

WHO KNOWS YOU?

To create a niche for yourself and make sure people are aware of what you do best, approach networking as a long-term strategy.
By Betsy Alberty

BRIDGING THE GULF

Biotechs eager for newly minted PhDs are finding applicants with a lack of skills in dealing in a world where science and commerce must coexist
By John Williamson

MOTIVATION MOJO

How to use the psychology of science to spur scientific excellence
By Ted Agres

FOUNDATIONS

"The Eppy"
By Reza Hashemi