CONTENTS
December 2007
One company is aiming to be the first to sell autologous organs, starting with the human bladder. ALISON MCCOOK toured their facility and asks: Will you one day be able to buy your own bladder? |
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In 2003, scientists proposed a universal animal barcode: a segment of roughly 650 base pairs of a mitochondrial gene. Today, BOB GRANT reports there are more than 300,000 barcode sequences in a central repository. Can this short stretch of DNA conserve biodiversity and keep us safe from poisons? |
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LEWIS CANTLEY tells the story of discovering PI3 kinase, an enzyme involved in numerous cellular pathways. In the process, Cantley uncovered PI3 kinase's crucial role in cell growth and metabolism, as well as a molecular route to cancer. |
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Twelve years ago, Salvador Moncada decided to create a research environment that was better funded than the average academic institute but with greater freedom from the bottom line. We sent STEPHEN PINCOCK to London, where he visited the Wolfson Institute for Biomedical Research to find out whether it has achieved Moncada's vision. |
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EDITORIAL An iGEM of an idea
How to get students to go into science COLUMNS My Eye's On You What to think about night vision, tetrachromatic vision, and other visual enhancements? Let's Mandate Masks Why every man, woman, and child should carry masks at all times Notebook The Agenda; Operation roadkill; Passive protection? (Slideshow: Passive immunization and West Nile Virus); PhDs and parishioners; A knockout strikes out; Joint venture FOUNDATIONS Photomicroscopy, circa 1876; Slideshow: A Microscopic History PROFILES Stuck on Giardia Heidi Elmendorf's passion for parasitology is matched only by her passion for teaching Scientist to Watch: Sean Crosson Bacteria in LOV THE LITERATURE Hot paper: Remodeling the Model T A new lineage of T helper cells shakes up an old paradigm Hot paper in ecology: Bayesian-based trees Scientists suggest a revised taxonomy for lizards Hot paper in neurobiology: Signaling neurogenesis Signaling molecule Wnt linked to neurogenesis in rodents Hot paper in microbiology: A new nitrifier The first observation of nitrification in the domain Archaea Papers to watch; Unleashing neurogenesis; Solving AMPK LAB TOOLS Chasing Rainbows MELISSA LEE PHILLIPS on how to make the most of multicolor immunofluorescence. Plus, profiles of immunofluorescence users: Background glow; Cutting crossover; Unsticking; Staying bright. And How to Maximize Immunofluorescence Multiplexing BIOBUSINESS The Hybritech Family Tree KELLY RAE CHI traces the birth of San Diego's vibrant biotech industry to one man CAREERS No longer lonely at the top How to pick an executive networking group that's right for you |