CONTENTS

March 2008

RANDALL MOON describes how an off-the-cuff experiment over Christmas break 20 years ago surprisingly produced a hundred tadpoles with two heads - and perhaps, ultimately, a new target for cancer and Alzheimer therapies.

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The Wnt pathway

Public health interventions designed to improve conditions in the developing world rarely tack on follow-up studies to figure out what went right - and what went wrong. BOB GRANT traveled to Haiti to investigate how one scientist's approach to reducing his country's death rate among children admitted to the hospital for diarrhea from 44% to 1% could revolutionize the way we improve public health.

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Successful Strategies

Video: First-responders to HIV in Haiti reminisce

Slideshow: Implementing change in Haiti

How does your institution compare in our sixth annual survey? Plus, JONATHAN SCHEFF reports that in a tight funding environment, institutions are finding creative ways to boost benefits for postdocs.

RELATED:

Always evolving at the Hutch

Gladstone: Attentive at the top

Cambridge shoots ahead

Slideshow: Top 2008 Institutions

Survey Methodology


Ranking Tables:

Top 35 US Institutions

Top 15 US Institutions

Top 10 International Institutions

BPTW: Survey Finding PDFs

Demographics:

Interactive map of results

Assessing the Postdoc Experience

CONTRIBUTORS

MAIL

EDITORIAL

Science Applied to the Greatest Needs Having failed the developing world, are we now getting it right?
RICHARD GALLAGHER

COLUMNS

It's Not Just About Innovation New ideas are cheap; what we really need are scientists who can see them through.
STEVEN WILEY

Translational Disconnect Bioscience innovation is in crisis. What can we do about it?
ALAN WALTON and FREDERICK FRANK

NOTEBOOK

The Agenda; Lab transformation; Slideshow: Insect Transformation Laboratory at UMBI; An abnormal reunion; Immunity for breakfast?; Supercharging proteins; Poppy power

FOUNDATIONS

A Brain Collection, 1862-present

PROFILES

Crystal Clear High school dropout Peter Kwong has solved the structures of some of nature's toughest proteins.
KAREN HOPKIN

Scientist to Watch: Zemer Gitai Modeling life's architecture

BIOBUSINESS: The People's CSO Millennium Pharmaceuticals' Joe Bolen has kept scientists' morale high through wrenching changes.
EDYTA ZIELINSKA

THE LITERATURE

Hot paper: Autophagy Revisited Even healthy cells require this catabolic process.
BOB GRANT

Hot paper in Neuroscience: Spine control 

Hot paper in Systems Biology: Promiscuous receptors 

Hot paper in Phylogenetics: Trading in trees 

Citation Classic: 50 Years Ago in Pharmacology The first chemical method for measuring levels of catecholamine.
View other Citation Classics

LAB TOOLS

Peak Addition  How to get numbers from mass spectrometry. Plus, profiles of Mass Spec users: Easy numbers; Clean targeting; Multiplex counts and Metabolic power. And Tips for Quantifying Mass Spec
JEFFREY M. PERKEL

CAREERS

If You Build It...  How to create a great laboratory Web site. Plus results from The Scientist's Laboratory Web and Video Awards (LaWVA).
JONATHAN SCHEFF