CONTENTS
June 2008
Evolution's real problem, ERIC SMITH argues, is that it doesn't quite explain the original emergence of life from a lifeless geosphere. But a remarkable picture is emerging, he says, that suggests that much simpler principles than those devised by Darwin may describe the early earth, and serve as the foundation for biosynthesis in every kind of ecosystem. |
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Recently, GlaxoSmithKline convinced Roche to sell its controversial obesity drug, and then convinced the US Food and Drug Administration to let GSK sell the drug over-the-counter, without a prescription. FRAN HAWTHORNE talks to key players and analysts to present the story you didn't see of the first diet drug's move to drugstore shelves. |
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The competitive world of industry fosters an appetite to get ahead. In our sixth annual survey, ELIE DOLGIN uncovers the recipe for a successful workplace. Plus, see charts of this year's top companies, and take a closer look at high ranking Organon and Lexicon Pharmaceuticals. |
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EDITORIAL From Me to We The Scientist Community is about to take off. We hope you'll join us. COLUMNS Why National Laboratories? For certain experiments, I've learned that there's no better place to do biology. OPINION Academic Medicine to the Rescue? Full partnerships with the industry are spawning a new era of translational medicine. Notebook The Agenda; Cave crawler; The worm hunter; Slideshow: Fruit Worms ; Finding the false; Inducing autism; Unlocking the clock FOUNDATIONS C. elegans cell lineage, circa 1981 PROFILES A Mind Apart Sean Eddy uses his decades of experience playing video games to design software that found an entire new class of genes. And he's still looking. Scientist to Watch: Peter Reddien Making heads or tails of it BIOBUSINESS: Win, Place, or Cell Can a company harness stem cells to treat injured horses? THE LITERATURE Hot paper: Parsing Out Pluripotency Clues to why pluripotent stem cells differentiate or remain pluripotent. Hot paper in Genomics: Human selection Hot paper in Ecology: Predicting distribution Hot paper in Neurobiology: Learning synapses Citation Classic: 25 Years Ago in Immunology Indentifying the retrovirus that causes AIDS LAB TOOLS Shaping Up How to find your way around three-dimensional cell culture. Plus, researchers describe their preferred methods for 3-D culturing: In stock; Home-made matrix; Mixed gel; Planar imaging; and Commercial 3D matrices. And Tips for setting up 3-D cell cultures CAREERS The Industry Roads Less Taken Four high-paying, in-demand, industry jobs scientists often overlook, and tips on how to get in: Regulatory Affairs; Preclinical Research; Project Management; and Process Development |