CONTENTS

August 2009

The newt can reconstruct almost any body part, including the brain, spinal cord, heart and limbs. Planarians, a high-school laboratory favorite, can be sliced to bits and each piece will regenerate a new individual. MEGAN SCUDELLARI speaks to scientists who study these and other organisms that regenerate naturally, to find out what they can teach those studying regenerative medicine. Some predict if these two groups join forces, the repair or replacement of human limbs and organs could be possible within years.

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Limbs regrow without pluripotency

Electricity can spark regeneration

WNTer wonderland

In his search for the potential benefits of bacteria (the vast majority of which are nonpathogenic), SARKIS MAZMANIAN at the California Institute of Technology narrows his focus to one polysaccharide on the surface of one bacterium. This molecule appears to make the difference between a healthy and unhealthy immune system in mice, and points towards a new treatment for autoimmune disease.

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Bacteria Gladiators

The number two-ome

Can Bacteria Rescue the Oil Industry?

We reveal the winners of our first The Scientist Video Awards, picked by professional judges and our readers. JEF AKST presents what makes each video great.

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Laboratory Web Site and Video Awards

Video journal goes closed access

Darwin, ha ha

CONTRIBUTORS

MAIL

EDITORIAL

Bailed Out by Science
The US healthcare system is hurting, but research can come to its rescue.
RICHARD GALLAGHER

COLUMNS

Timing is Everything
You want to be ahead of the curve, but not so far ahead that no one can see you.
STEVEN WILEY

Healthcare Reform: 2 Views
Striking the Right Balance
SEAN HARPER
An Example of Wasteful Spending
DENNIS J. COTTER, MAE THAMER, and YI ZHANG

NOTEBOOK

Am I a biohazard?
Epigenetic suicide note
Evolving heart
Death, delimited
Got moose?

FOUNDATIONS

The Golgi Stain, circa 1873
MOHEB COSTANDI

PROFILE

Master Plans
Sean Carroll earned his celebrity by stitching together the patterning that underlies much of the animal kingdom's various shades and shapes.
KAREN HOPKIN

SCIENTIST TO WATCH

Rebecca Vega Thurber
The coral doctor
JEF AKST

BIO BUSINESS

Adaptive Evolution
A once-rare type of clinical trial that violates one of the sacred tenets of trial design is taking off, but is it worth the risk?
ALLA KATSNELSON

THE LITERATURE

The Protein Tango
Researchers unravel the complexities of coupled protein binding and folding and lead others towards new drug targets.
BOB GRANT

Hot paper in Drug Discovery: Proteomic profiling
JEF AKST

Hot paper in Ecology: Shark Attack
JEF AKST

Hot paper in Molecular Biology: Micro-management
JEF AKST

LAB TOOLS

Screening Whole
How to reel in high-throughput results using worms and fish
KELLY RAE CHI

CAREERS

Scoring on Sabbaticals
How to make the most of the precious time away from your usual duties
ELIE DOLGIN