CONTENTS
May 2009
Plenty has been said about the problems of the pharmaceutical industry and the need to reinvigorate the model. But how do you go about it? GlaxoSmithKline is overhauling the drug discovery and development process, one more time. The crucial difference: empowering its scientists. Newly appointed chief strategist of research and development YVONNE GREENSTREET lays out the company's radical approach. |
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RNA is supposed to silence genes by cutting up
mRNA, not act on transcription—and definitely
not boost gene expression. So why, as ELIE DOLGIN
reports, are scientists seeing just that? |
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Even bacteria that don't get their energy from
sunlight appear to respond to light in curious
ways. ALLA KATSNELSON asks: What on earth is
the role of light-sensing proteins in bacteria, if
not for photosynthesis? Have scientists stumbled
upon a new ubiquitous signaling mechanism? |
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EDITORIAL Citation Violations Scientists are guilty of bibliographic negligence. Here's how to police the pages of journals. COLUMNS Heroes and Villains Why we sometimes need scientists to publicly misbehave. Teaching Peer Review It helps school students distinguish between what is opinion and what is scientific. Notebook Darwin, ha ha; Molecular makeover; Pharma on Facebook?; Apparently APP; Sea Robocop FOUNDATIONS PROFILE Bright Ideas Keith Moffat used his background in physics to tinker with tools that light up molecules in motion. SCIENTIST TO WATCH Dennis Wall From moss to autism BIOBUSINESS When Universities Unite European academic institutions are banding together to help commercialize discoveries. But in such a high-stakes game, can all players get along? THE LITERATURE Hot papers: Charting the Human Metabolome The success of a database of metabolites has whetted researchers' appetites for more. Hot paper in Cancer Biology: Chromosomal complications Hot paper in Plant Biology: Relocating immune receptors Hot paper in Genomics: Quantifying quadruplexes LAB TOOLS Sequencing on Target Techniques for pulling out and sequencing selected areas of the genome PCR Vinaigrette; Padlock Probes; Hybrid Selection ; Selector Probes; Filter Capture CAREERS The Women That Stay Thinking about leaving science? Here are programs that helped keep women in research careers in United States and abroad. |