CONTENTS

July 2009

Every year, the Office of Research Integrity penalizes a handful of biomedical scientists for misconduct, typically barring them from funding for a few years. In theory, once the penalty period is up, the punishment—and the shame—should be over. However, in the age of the Internet, announcements of debarments that ended years ago are easily retrievable with an online search of the scientist's name. Three scientists agreed to talk to ALISON MCCOOK about how they've tried to move on despite the permanent public record.

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Fairness for Fraudsters

Biotech's Baddies

Fixing Fraud

Tracking the movement of DNA and the location of structural proteins in the nucleus reveals that DNA placement makes the difference between activity and silence. SUSAN GASSER, director of the Friedrich Miescher Institute for Biomedical Research in Basel, describes her decades-long quest to understand this fundamental process.

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Demystifying Histone Demethylases

A new epigenetic cancer

Is It a Code: The Debate

Since the 17th century, fishing has been an integral part of New England life. But 400 years of scooping fish from the sea have taken a toll, and nearly all groundfish are hurting. Except one. KIRSTEN WEIR asks: If experts can replicate what went right with this one species, could others be pulled back from the brink?

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Sea Robocop

Catching crabs

The whirling fish kill

CONTRIBUTORS

MAIL

EDITORIAL

Fairness for Fraudsters
The punishment for researchers guilty of misconduct is excessively punitive, and needs reform.
RICHARD GALLAGHER

COLUMNS

Quitters Sometimes Win
Not everybody who likes independent research is suited for it.
STEVEN WILEY

Don't Format Manuscripts
Journals should use a generic submission format until papers are accepted.
FRANCOIS BRISCHOUX & PIERRE LEGAGNEUX

NOTEBOOK

Number two-ome
Like life
Hard bargains
Sample, don't trample
Pride vs. tribe

FOUNDATIONS

First human brain chemicals, 1865-1871
ELIE DOLGIN

PROFILE

Prokaryotic Pioneer
Always a trailblazer, Susan Gottesman laid the foundation for two new fields in bacterial gene regulation.
KAREN HOPKIN

SCIENTIST TO WATCH

Konrad Hochedlinger
A reprogramming revolutionary
ELIE DOLGIN

BIO BUSINESS

Success with iPSCs
The nascent science still has many stumbling blocks to step over before companies can reap the rewards of reprogramming.
ELIE DOLGIN

THE LITERATURE

Hot paper: Gut Churning
The discovery of an intestinal stem cell marker fuels an ongoing debate over the cells' location and properties.
ALLA KATSNELSON

Hot paper in Plant Molecular Biology: Getting defensive
BOB GRANT

Hot paper in Immunology: Stately STAT
JEF AKST

Hot paper in Stem Cell Biology: Caught between a ROCK
ELIE DOLGIN

LAB TOOLS

Green at the Bench
Replacing your lab's chemical "worst offenders" with less toxic alternatives
AMY COOMBS

CAREERS

What Vacation?
How to make summer internships fruitful affairs for advisors and students
BOB GRANT

Clarification (posted July 8): The Table of Contents has been changed to reflect the fact that Susan Gasser's primary appointment is the Friedrich Miescher Institute for Biomedical Research in Basel, not the University of Basel, as originally published.