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A Green Gene Revolution
The Scientist Staff | Jul 13, 2003 | 2 min read
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The Holy Grail of Immunology
The Scientist Staff | Jul 13, 2003 | 2 min read
Foundations | The Holy Grail of Immunology Click for larger version (27K) In 1983, Tak Mak's lab cloned the beta chain of the T-cell receptor, helping to accomplish what the immunology community had been anticipating for 20-plus years. But the T-cell receptor's structure was believed to be heterodimeric, and no one had deciphered what the other piece looked like. In 1984, Mak sketched his thoughts on its shape for a student, Pamela Ohashi, who then made antibodies to peptides, using the a
Who's in the Kitchen? Scientists!
The Scientist Staff | Jul 13, 2003 | 2 min read
Click for larger version (20K) A remarkable 88% of the 361 readers of The Scientist who responded to our survey prepare a meal at home once every week or more. More than half, 57%, bustle about in the kitchen nearly every day. And these scientists are not just boiling an egg or opening a bag of lettuce; 79% declare that those who eat their meals consider them good, excellent, or outstanding chefs. As would be expected from an international group of scientists, readers enjoy cooking in more
UCL university college London David Latchman misconduct research investigations fraud plagiarism data manipulation evidence reports released
University Releases Reports from Investigation of Prominent Geneticist
Chia-Yi Hou | Jul 2, 2019 | 2 min read
A panel finds David Latchman’s “recklessness in the conduct” of the lab and his involvement as an author on problematic papers facilitated the misconduct.
RNA Interference without the Interferon; Simplifying Dialysis and Electroelution; Microarray Analysis, TIGR-Style
Ivan Oransky | Jul 13, 2003 | 4 min read
PATENT WATCH | RNA Interference without the Interferon The red-hot field of RNA interference (RNAi) could benefit from patents issued jointly to Queensland, Australia-based Benitec, and the State of Queensland (US patent 6,573,099, issued June 3, 2003, and UK patent 2353282, granted May 3, 2003). The patents describe a method Benitec calls "DNA-directed RNA interference" (ddRNAi) to differentiate it from typical double-stranded small interfering RNA (siRNA). Using this method, a DNA constru
Inflammation's infamy
Karen Kreeger | Jul 13, 2003 | 9 min read
Courtesy of Keith Crutcher IMMUNITY IN MIND: Cultured microglial (N9) cells (red) on a tissue section containing an Alzheimer plaque (green). There is continuing controversy about whether these types of inflammatory cells are responding to plaques or causing them. A finger catches the sharp edge of an envelope; a noseful of tree pollen is accidentally inhaled; the latest virus finds host after human host. In all cases the assaulted body reacts through inflammation, a well known, but not
A Finger on the Pulse of Transcriptional Control
Leslie Pray | Jul 13, 2003 | 7 min read
"I lost concentration and began to think of our scholarly daughter working at Yale on a project called Zinc Fingers scanning a protein with pseudopods each with a trace of zinc that latch on to our DNA and help determine what we become." --From Zinc Fingers, Peter Meinke  "GREEN" FINGERS: Zinc finger- based artificial transcription factors (background) have been applied in plants such as Arabidopsis thaliana (foreground). Reprinted with permission, Curr Opin Plant Biol, 6:163-8, Apri
Iraqi Science: Who Cares?
Richard Gallagher | Jul 13, 2003 | 3 min read
As my intrepid colleague Sam Jaffe reports in this issue (Rebuilding Iraqi Science), Iraqi science is on its knees. Following two-and-a-half decades of a brutal dictatorship, it's been pummeled by sanctions, halted in its tracks by war, and ransacked in the postwar chaos. We probably can add to this list a deep malaise, which appears to be affecting the entire country as it awaits reconstruction. While reading his report, several questions struck me: Just how worthwhile would it be to reconst
The Fruits of University Research
Ted Agres | Jul 13, 2003 | 6 min read
When universities license discoveries made by scientists to companies for commercialization, the whims of the marketplace determine the results. As with anything else in business, the odds of scoring a major financial hit are slight, but the payoff can be exceedingly large. This is especially true for the life sciences, where discoveries and patents in medicine and biology continue to produce the lion's share of revenues for universities and research institutions. Life science patents also co
Fowl Dentata
Brian Mullin | Oct 19, 2003 | 2 min read
Fowl Dentata A few months ago I saw in The Scientist1 the single most frightening image I have ever seen. It was a chicken with teeth. Although worse pictures have been served up over the years--death, destruction, mutilation--this was the most indigestible. A modern-day metaphor for science hailed as a breakthrough, as perhaps it truly is. I trust good will come from this in terms of genetic control of odontoblasts and suppression of evolutionary DNA repression. But give me a break.

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