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Covering the life sciences inside and out

Millions of measurements from 23 people who consumed extra calories every day for a month reveal changes in proteins, metabolites, and gut microbiota that accompany shifts in body mass.

image: Learning Opens the Genome

Learning Opens the Genome

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Researchers map learning-induced chromatin alterations in mouse brain cells, and find that many affect autism-associated genes.

Ashutosh Tiwari, who falsely claimed to be affiliated with Linköping University, is also under investigation for alleged scientific misconduct and fraud.

Transparency about the role of animals in drug development could help raise awareness of and appreciation for preclinical research.

The Nutshell

Daily News Roundup

Shortly after ruling out the earliest priority dates on a foundational patent for CRISPR gene-editing technology, the European Patent Office rescinded the patent entirely—and more are likely to follow.

A consortium of 300 universities and college libraries had taken a strong stance against the publishing giant’s price hikes. 

More than 8 million people are on the brink of starvation, according to aid agencies.

A new study suggests that the plague, which killed millions of people, was not transmitted by rats.

Current Issue

January 2018

Issue Cover: The Science of Pain

Immune-like cells in the central nervous system are now recognized as key participants in the creation and maintenance of persistent pain.

The race to develop analgesic drugs that inhibit sodium channel NaV1.7 is revealing a complex sensory role for the protein.

A cornucopia of toxins in the animal kingdom could provide inspiration for novel painkillers, but so far, effective drugs have proven elusive.  

Decades after their discovery by bioprospectors, amphibian-derived analgesics continue to attract scientific attention.

Multimedia

Video, Slideshows, Infographics

The instrument presents a new option for researchers working on large-scale fly behavior studies.

Since the mid-2000s, the voltage-gated sodium channel NaV1.7 has emerged as a promising target for a new class of analgesics.

The Marketplace

Sponsored Product Updates

Desktop Genetics Ltd (DTG), a biotech company globally recognised for its leadership in gene-editing bioinformatics, acquired exclusive worldwide licensing rights for TIDE (Tracking of Indels by DEcomposition), from the Netherlands Cancer Institute (NKI). The TIDE technology will allow investigators to quantitatively assess genome editing on the DESKGEN Cloud, the free CRISPR design software from DTG.

Ziath announced it will showcase its new, cost-effective 2D barcode rack scanner, the DataPaq™ Mirage, at SLAS2018 (3–7 February 2018, San Diego, CA). This innovative camera-based scanner has a low-profile design enabling it to be easily integrated with robotic liquid handling systems, as well as other laboratory automation solutions. As a result, the DataPaq™ Mirage allows the benefits of a more sophisticated camera-based 2D barcode rack scanner to be brought to automation workflows for the same price as an old flatbed scanner.

SYGNIS AG (Frankfurt: LIO1; ISIN: DE000A1RFM03; Prime Standard), the Group which includes Expedeon Holdings, Innova Biosciences, and C.B.S. Scientific Company, today announced it has extended the manufacturing capability for its Lightning-Link® technology, currently marketed under the Innova Biosciences brand, to support scalability and bulk production of antibodies.

Charge-coupled device (CCD) sensors have revolutionized digital imaging technology. Learn about how they work, what parameters dictate their performance, and how CCDs improve gel and membrane imaging with this application note from ProteinSimple!

 Avacta Group plc (AIM: AVCT), the developer of Affimer® biotherapeutics and reagents, is pleased to announce that its initial study with Glythera Limited, the developer of next generation antibody drug conjugates, has concluded successfully. 

Laser capture microdissection is powerful, but sample scarcity can be a problem for downstream applications. Find out how capillary-based immunoassays can solve this problem with this application note from ProteinSimple!

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Featured Comment

Sad day for the research community on cell division. What a disservice to science.

Sonia Rossell, commenting on The Scientist's Facebook page about renowned Univeristy of Tokyo cell biologist Yoshinori Watanabe being found guilty of manipulating images in five research papers from his lab.

Investigation Finds Cell Biologist Guilty of Misconduct
AAAS