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tag chemistry developmental biology evolution immunology

One Protein to Rule Them All
Shelby Bradford, PhD | Feb 28, 2024 | 10+ min read
p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.
Week in Review: September 21–25
Tracy Vence | Sep 24, 2015 | 2 min read
Reflecting on the STAP saga; neurons connect the brain to fat; how microbes affect wine chemistry; Nobel predictions
Cell Biology Leads Way As Biological Sciences Progress, But Experts Are Wondering Where All The Jobs Have Gone
Susan L-J Dickinson | Dec 12, 1993 | 8 min read
As more researchers flock to the popular field, observers fear a widening gap between supply and demand When scientists convene in New Orleans next week for the 33rd annual meeting of the American Society for Cell Biology (ASCB), nine symposia, 20 minisymposia, and countless informal gatherings are sure to focus on the recent achievements and continuing progress in this exciting and rapidly expanding scientific field. There is likely to be little excitement in the air, however, concerning the
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Surpassing the Law of Averages
Jeffrey M. Perkel | Sep 1, 2009 | 7 min read
By Jeffrey M. Perkel Surpassing the Law of Averages How to expose the behaviors of genes, RNA, proteins, and metabolites in single cells. By necessity or convenience, almost everything we know about biochemistry and molecular biology derives from bulk behavior: From gene regulation to Michaelis-Menten kinetics, we understand biology in terms of what the “average” cell in a population does. But, as Jonathan Weissman of the University of Califo
2020 Top 10 Innovations
The Scientist | Dec 1, 2020 | 10+ min read
From a rapid molecular test for COVID-19 to tools that can characterize the antibodies produced in the plasma of patients recovering from the disease, this year’s winners reflect the research community’s shared focus in a challenging year.
Notable
Jeffrey Perkel | Jan 6, 2002 | 4 min read
J.A. Camarero et al., "Peptide chemical ligation inside living cells: In vivo generation of a circular protein domain," Bioorganic and Medicinal Chemistry, 9[9]:2479-84, September 2001. F1000 Rating: Recommended "To investigate whether chemo-selective peptide ligations work in vivo, the authors demonstrate the in vivo head-to-tail cyclization of a bioactive SH3 domain using native chemical ligation. The protein precursor was constructed using a clever combination of an intein-fusion protein an
Ribozymes: Hearkening Back to an RNA World
Jeffrey Perkel | Sep 15, 2002 | 9 min read
Illustration: Ned Shaw LIKE MOLECULAR TOY-MAKERS, ribozyme researchers create tools with evolutionary, diagnostic, and therapeutic applications. Nearly 20 years ago, Tom Cech and Sidney Altman discovered that some naturally occurring RNAs could perform enzymatic reactions, earning these researchers the 1989 Nobel Prize in chemistry. Scientists have now identified several examples of RNA enzymes, or ribozymes. Most make or break the phosphodiester bonds in nucleic acid backbones, but some
Working in a Virtual Laboratory
Jennifer Fisher Wilson | Dec 6, 1998 | 6 min read
NEXT STEP: The virtual center "is the natural evolution of our shared research interests," says Ashley T. Haase, chair of the microbiology department at the University of Minnesota. When AIDS researchers physically located in four different states hold a meeting, it almost feels like they're sitting at a table across from each other--but they're really just facing their individual computer screens. They view slides of the human immunodeficiency virus in lymphoid tissue in real time and discuss
How to Create a Successful Fish Tale?
A. J. S. Rayl | Aug 19, 2001 | 10+ min read
More than 80 percent of the planet's living organisms exist only in aquatic ecosystems. Some may harbor secrets to human origins, and clues, treatments--perhaps even cures--for human disease. Some are critical bioindicators that portend the health of the biosphere. Yet, overall, scientists know little about the biochemical processes of these life forms. The vast, rich knowledge within the oceans and freshwater systems on Earth remains virtually untapped, because in the world of biological resear

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