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Genetic Reprogramming Restores Vision in Mice: Study
Genetic Reprogramming Restores Vision in Mice: Study
Researchers repaired what is otherwise irreversible damage in the animals’ ocular neurons, by activating transcription factors ordinarily used to generate induced pluripotent stem cells.
Genetic Reprogramming Restores Vision in Mice: Study
Genetic Reprogramming Restores Vision in Mice: Study

Researchers repaired what is otherwise irreversible damage in the animals’ ocular neurons, by activating transcription factors ordinarily used to generate induced pluripotent stem cells.

Researchers repaired what is otherwise irreversible damage in the animals’ ocular neurons, by activating transcription factors ordinarily used to generate induced pluripotent stem cells.

aging, genetics & genomics

Male Flies’ Y Chromosome May Contribute to Earlier Deaths
Jef Akst | Jul 13, 2020 | 2 min read
As male Drosophila grow old, selfish genetic elements that are abundant on the Y chromosome become more active, which appears to reduce longevity.
Infographic: How Does Cell Senescence Drive Aging and Disease?
Katarina Zimmer | Mar 1, 2020 | 4 min read
The accumulation of zombie-like cells seems to accelerate aging and promote aging-related disease. Researchers are trying to figure out how.
Increased Neuronal Activity Shortens Lifespan in Animals
Ruth Williams | Oct 16, 2019 | 3 min read
Suppressing the natural age-related increase in neuronal excitation lengthens the lives of worms, and there are indications that the same may be true for mice and humans.
Another Bird Telomere Study, Different Results
Anna Azvolinsky | Mar 21, 2018 | 2 min read
Two studies examining the effects of parents’ ages on their offsprings’ telomere lengths come to opposite conclusions.  
Study: Telomeres Don’t Shorten with Age in Longest-Lived Bats
Diana Kwon | Feb 7, 2018 | 1 min read
Researchers find that while bats in the Myotis genus don’t produce telomerase, the enzyme that lengthens telomeres, they possess 21 telomere maintenance–related genes.
Mutation Linked to Longer Life Span in Men
Jef Akst | Jun 18, 2017 | 2 min read
A deletion in a growth hormone receptor gene is tied to an average of 10 extra years of life among men, but not women, according to a study.
An Aging-Related Effect on the Circadian Clock
Anna Azvolinsky | Feb 21, 2017 | 3 min read
Stress-related genes may be preferentially and rhythmically expressed as part of the circadian rhythms of older fruit flies, researchers report.  
Vlad Denic on Exploring New Fields and Failing Successfully
Ben Andrew Henry | Dec 1, 2016 | 3 min read
The Harvard professor is pursuing fundamental questions about autophagy, protein homeostasis, and other cellular processes, and he’s always on the lookout for his next new topic.
First Data from Anti-Aging Gene Therapy
Kerry Grens | Apr 25, 2016 | 4 min read
A biotech company reports that an experimental treatment elongated its CEO’s telomeres. 
Aging Shrinks Chromosomes
Ruth Williams | Feb 5, 2016 | 3 min read
A study on human cells reveals how cellular aging affects the 3-D architecture of chromosomes.
Genes’ Cycles Change with Age
Kerry Grens | Dec 23, 2015 | 1 min read
As the rhythmic expression of many genes falls out of sync in older human brains, a subset of transcripts gain rhythmicity with age.
Alphabet Announces Life Sciences
Tracy Vence | Aug 24, 2015 | 1 min read
Google’s parent company is launching a research-and-development project as a standalone firm.
Weiwei Dang: Epigenetics in Aging
Jef Akst | Mar 1, 2015 | 3 min read
Assistant Professor, Huffington Center On Aging, Baylor College of Medicine. Age: 38
Rethinking Telomeres
Kate Yandell | Mar 1, 2015 | 3 min read
Not only do telomeres protect the ends of chromosomes, they also modulate gene expression over cells’ lifetimes.
How We Age
The Scientist | Mar 1, 2015 | 10+ min read
From DNA damage to cellular miscommunication, aging is a mysterious and multifarious process.
Wrangling Retrotransposons
Andrei Seluanov, Michael Van Meter, and Vera Gorbunova | Mar 1, 2015 | 8 min read
These mobile genetic elements can wreak havoc on the genome. Researchers are now trying to understand how such activity contributes to the aging process.
Methylation Predicts Mortality
Kerry Grens | Feb 3, 2015 | 1 min read
A study finds a link between patterns of methylation in the human genome and people’s life span.
Mom’s Mitochondria Affect Pup Longevity
Ruth Williams | Oct 9, 2014 | 3 min read
Mitochondrial mutations inherited from the mother can shorten a mouse’s lifespan.
Week in Review: May 19–23
Tracy Vence | May 23, 2014 | 3 min read
Sperm-sex–sensing sows; blocking a pain receptor extends lifespan in mice; stop codons can code for amino acids; exploring the tumor exome
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