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image: Alcohol Damages Mouse DNA

Alcohol Damages Mouse DNA

By Jef Akst | January 3, 2018

A byproduct of alcohol consumption causes mutations in the DNA of mouse blood stem cells, and some of the breaks are not repaired.


With the arrival of a new class of single-nucleotide editors, researchers can target the most common type of pathogenic SNP in humans.

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image: Damage Patroller

Damage Patroller

By Anna Azvolinsky | October 1, 2017

Stephen Elledge has built a career studying how eukaryotic cells maintain genomic integrity.


image: Infographic: The Various Forms of Methylated DNA

Infographic: The Various Forms of Methylated DNA

By Skirmantas Kriaucionis | September 1, 2017

To expand the basic nucleotide alphabet, many species modify their DNA with epigenetic marks.


image: The Role of DNA Base Modifications

The Role of DNA Base Modifications

By Skirmantas Kriaucionis | September 1, 2017

Researchers are just beginning to scratch the surface of how several newly recognized epigenetic changes function in the genome.


image: CRISPR: No Cutting Required

CRISPR: No Cutting Required

By Anna Azvolinsky | August 4, 2016

Combining a modified Cas9 enzyme with an unrelated one derived from the immune system of the sea lamprey, researchers demonstrate yet another way to edit a single DNA nucleotide. 


image: Advances in Genome Editing

Advances in Genome Editing

By Catherine Offord | April 20, 2016

Researchers develop a CRISPR-based technique that efficiently corrects point mutations without cleaving DNA.


image: New Way to Edit Genes

New Way to Edit Genes

By Jef Akst | October 1, 2015

Researchers develop a more-efficient method for rewriting DNA that could hold therapeutic value for HIV and other diseases.


image: Age-Old Questions

Age-Old Questions

By Mary Beth Aberlin | March 1, 2015

How do we age, and can we slow it down?

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image: How We Age

How We Age

By The Scientist Staff | March 1, 2015

From DNA damage to cellular miscommunication, aging is a mysterious and multifarious process.


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