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tag prefrontal cortex genetics genomics disease medicine cell molecular biology

DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
2022 Top 10 Innovations 
2022 Top 10 Innovations
The Scientist | Dec 12, 2022 | 10+ min read
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
Exploring the Past, Present, and Future of Brain Organoids 
Niki Spahich, PhD | Feb 18, 2024 | 5 min read
Paola Arlotta seeks to understand the complex symphony of brain development in vitro by using organoid models.
Top 7 cell biology papers
Jef Akst | Jul 12, 2010 | 3 min read
#1 Gene for autoimmunity Rare genetic variants in the protein sialic acid acetylesterase (SASE) are linked to common human autoimmune diseases, including type 1 diabetes, arthritis, and Crohn's disease. In mice, defects in the protein have been linked to problems in B-cell signaling and the development of auto-antibodies. I. Surolia, et al., "Functionally defective germline variants of sialic acid acetylesterase in autoimmunity," Nature, 466:243-7. Epub 2010 Jun 16. linkurl:Eval;http://f1000b
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
A rendering of a human brain in blue on a dark background with blue and white lines surrounding the brain to represent the construction of new connections in the brain.
Defying Dogma: Decentralized Translation in Neurons
Danielle Gerhard, PhD | Sep 8, 2023 | 10+ min read
To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.
From Many, One
Elena E. Giorgi | Apr 1, 2015 | 10+ min read
Diverse mammals, including humans, have been found to carry distinct genomes in their cells. What does such genetic chimerism mean for health and disease?
early-life stress, histone, chromatin, epigenetics, epigenetic modification, methylation, DNA, protein, stress, adversity, mice, genetics, genomics
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Asher Jones | Mar 18, 2021 | 5 min read
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
New Molecular Tools Enable Researchers To Correlate Viruses, Diseases
Karen Young Kreeger | Feb 4, 1996 | 7 min read
Viruses, Diseases Author: Karen Young Kreeger Sidebar: Professional Resources for Viral Disease Researchers In the mid- to late 1980s, numerous correlations were discovered between viruses and various types of cancers. For example, Epstein-Barr virus was associated with nasopharyngeal carcinoma and B-cell lymphoma, hepatitis B virus with liver cancer, and human papillomavirus with cervical cancer. Now, a decade later, basic and clinical scientists are finding out that viruses may also play a r

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