The Scientist Staff | Dec 12, 1993 | 2 min read
Mario Capecchi, a professor of human genetics at the University of Utah School of Medicine and a Howard Hughes Medical Institute investigator, is best known for his pioneering work on developing gene targeting in mouse embryo-derived stem (ES) cells. This technique allows the investigator to create mice with any desired mutation. "The power of this technology," says Capecchi "is that the investigator chooses both which gene to mutate and how to mutate it. The investigator has almost complete