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tag spinal cord injury culture disease medicine evolution

Making New Spinal Neurons
Ed Yong | Feb 25, 2014 | 3 min read
With a single gene, scientists reprogram supporting cells in the spines of living mice into new neurons.
Bespoke Stem Cells for Brain Disease
Nsikan Akpan | Jan 14, 2013 | 3 min read
Scientists use virus-free gene therapy on patient-derived stem cells to repair spinal muscular atrophy in mice.
Image of someone scratching their skin.
A Chronic Itch: Burrowing Beneath the Skin
Brian S. Kim, MD | Sep 8, 2023 | 9 min read
We have barely scratched the surface of itch science and what it indicates about our health.
The Neurobiology of Rehabilitation
Ricki Lewis | Jun 29, 2003 | 10+ min read
Courtesy of Eric D. Laywell SPHERES OF PROMISE These neurospheres, clusters of cells in culture derived from the CNS of mice, are stained with antibodies against a neuronal protein (red), and a astrocyte protein (green). They have a nuclear counterstain (blue). The brain and spinal cord were once considered mitotic dead ends, a division of neurons dwindling with toddlerhood, with memory and learning the consequence of synaptic plasticity, not new neurons. But the discovery of neural stem
News Notes
The Scientist Staff | Sep 2, 2001 | 3 min read
For the first time, researchers at Johns Hopkins University have shown that human embryonic stem cell transplants have enabled mice with paralyzed hind limbs to get up and walk, offering hope that stem cell therapy could be a panacea for victims of lower motor diseases such as Amyotrophic lateral sclerosis (ALS, or Lou Gehrig's Disease) and spinal motor atrophy. John Gearhart, professor and director of the division of pediatric urology at the Johns Hopkins School of Medicine, explained the resea
The Future Looks Bright for Genetic Medicine
Ronald Crystal | Nov 21, 2004 | 5 min read
Today, gene therapy, genomics, and stem cell therapy are considered to be discrete fields of research.
Neural Tissue Engineering
Aileen Constans | Jun 20, 2004 | 8 min read
GETTING ON YOUR NERVES:Left: courtesy of Anthony Windebank; right courtesy of Christine SchmidtTo facilitate nerve regrowth, tissue engineers employ biodegradable polymer scaffolds. Shown at left, a micrograph of an actual scaffold used to stimulate spinal cord regeneration in rats. Center, a piece of neural tissue grows on an electrically conductive polymer used primarily for peripheral nerve repair (image colored for effect). At right, stained section of a peripheral nerve showing axons in red
How Groups of Cells Cooperate to Build Organs and Organisms
Michael Levin | Sep 1, 2020 | 10+ min read
Understanding biology’s software—the rules that enable great plasticity in how cell collectives generate reliable anatomies—is key to advancing tissue engineering and regenerative medicine.
Increasing Number of iPS Cell Therapies Tested in Clinical Trials
Katarina Zimmer | Nov 28, 2018 | 6 min read
Since their discovery in 2006, induced pluripotent stem cells have been poised to reprogram regenerative medicine. Twelve years on, here’s how far they’ve come.
Porcine Possibilities
Ricki Lewis | Oct 15, 2000 | 8 min read
Courtesy of PPL TherapeuticsA new generation of pigs. Headlines in late summer 2000 introduced long-awaited reports on pig cloning and retroviral transmission to mice, pig cells healing rat spinal cords, and a gaff by Dolly dad Ian Wilmut erroneously heralding halt of xenograft work at the Roslin Institute near Edinburgh, Scotland. So it seemed that the question of whether pigs can pass their retroviruses to humans might finally be on the road to resolution. Not quite. Pigs, as the purveyors o

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