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tag genetic variation culture immunology disease medicine

DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
Woman with her back to camera, with arms stretched out, soaking up the sunshine
A Genetic Predisposition to Vitamin D Deficiency Contributes to Severe COVID-19
Iris Kulbatski, PhD | Jun 1, 2023 | 3 min read
Ana Teresa Freitas discussed how individual variation in vitamin D synthesis and metabolism influences susceptibility to upper respiratory viruses.
Illustration of HIV virus
Viral Protein Behind Chronic Inflammation in People with HIV: Study
Natalia Mesa, PhD | Dec 12, 2022 | 3 min read
The HIV protein Nef can cause long-term genetic changes that lead to hyperreactive immune cells, according to research in human cells and mice. 
GENETIC PREDISPOSITION TO VITAMIN D DEFICIENCY CONTRIBUTES TO SEVERE COVID-19
Genetic Predisposition to Vitamin D Deficiency Contributes to Severe COVID-19
Iris Kulbatski, PhD | Aug 15, 2022 | 3 min read
Ana Teresa Freitas discusses how individual variation in vitamin D synthesis and metabolism influences susceptibility to upper respiratory viruses.
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
T regulatory cell in red sandwiching an antigen presenting cell in blue
Gut Bacteria Help T Cells Heal Muscle: Study
Natalia Mesa, PhD | Mar 14, 2023 | 4 min read
Regulatory T cells in the colon travel to muscles to promote wound healing in mice, raising questions about how antibiotics may impact injury recovery.
Artist&rsquo;s rendition of multiple <em>Neisseria gonorrhoeae</em>, the bacteria that causes gonorrhea, depicted as two spheres stuck together, each covered in tendrils.
Gonorrhea-Blocking Mutation Also Protects Against Alzheimer’s: Study
Holly Barker, PhD | Aug 5, 2022 | 4 min read
Research traces the evolution of a gene variant that reduces the risk of Alzheimer’s disease, finding that it originally evolved in response to infectious bacteria.
A person moving the hands of a vintage clock backwards.
Synthetic Circuits Reveal the Key to Rewinding the Cellular Clock
Charlene Lancaster, PhD | Mar 12, 2024 | 4 min read
Using a circuit-based system, scientists determined the ideal transcription factor levels to promote the successful reprogramming of fibroblasts into induced pluripotent stem cells.
Patient-derived colon organoids from a healthy individual
Generating Mini-Guts for Drug Screening
The Scientist and MilliporeSigma | Dec 16, 2022 | 4 min read
Human gut organoids facilitate precise disease modeling and power high-throughput drug development efforts.
Variations on a Gene
Amy Francis | Jul 23, 2000 | 10+ min read
Photodisc Although President Bill Clinton surely had something in mind during his 2000 State of the Union address when he asked the nation to "celebrate our diversity," insights into human diversity at the molecular level are promising to speed drug discovery and revolutionize medicine to mark- edly improve human health. Individuals differ at one in 1,000 base pairs, which adds up to a whopping number of human genetic variations when applied to the roughly three billion base pairs of the human g

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