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tag genetic variation developmental biology evolution cell molecular biology

Biology's Blockbuster: Visualizing Genetic Variations
Kelli Miller | Feb 17, 2002 | 3 min read
They say timing is everything, and when it comes to cancer that's especially true. Human cells grow and divide every 24 hours. But in a fraction of a second, an error can occur in the copying of the human genome. Spotting precisely when that error happens is key to understanding, and possibly preventing, the development of cancer. Traditional cell cycle analysis involves staining samples taken at random intervals. But these snapshots don't tell the whole story. To see exactly what takes place ea
DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
Researchers CHOOSE Organoids to Investigate Neurodevelopment
Deanna MacNeil, PhD | Jan 29, 2024 | 4 min read
A 3D variation of pooled CRISPR screens could connect the dots between autism spectrum disorder genetics and cell fate pathways in the developing brain.
Top 7 in Molecular Biology
Cristina Luiggi | Aug 16, 2011 | 3 min read
A snapshot of the most highly ranked articles in molecular biology, from Faculty of 1000
Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.
A person moving the hands of a vintage clock backwards.
Synthetic Circuits Reveal the Key to Rewinding the Cellular Clock
Charlene Lancaster, PhD | Mar 12, 2024 | 4 min read
Using a circuit-based system, scientists determined the ideal transcription factor levels to promote the successful reprogramming of fibroblasts into induced pluripotent stem cells.
A Periodic Table for Biology
John Torday | Jun 20, 2004 | 5 min read
COOPERATIVE CELLS:Courtesy of Michael CarrollThe evolution of complex biologic organisms began with the symbiotic relationship between pro- and eukaryotes (I). This relationship gave rise to mitochondria (II), and the resulting diversity of unicellular organisms (III) led to their metabolic cooperativity (IV) mediated by ligand-receptor interactions and cell-cell signaling. Natural selection generated an increasing complexity (V). Failed homeostatic signaling (VI) recapitulates hylogeny/ontogeny
Lasker Awards Target Developmental, Diagnostic Genetics
Rebecca Andrews | Sep 29, 1991 | 6 min read
The Laskers are among the most prestigious medical research awards in the world and among the oldest in the United States. Since they were first presented in 1944, 49 winners have gone on to win Nobel Prizes. Jordan Gutterman of the M.D. Anderson Cancer Center in Houston, executive vice president of the Albert and Mary Lasker Foundation, and director of the awards program since earlier this year, attributes the prestige of the awards to their longevity and to the "extraordinary quality&quo
Top Five Institutions in Biological Sciences Doctorate Programs
Karen Young Kreeger | Oct 15, 1995 | 2 min read
Programs Author: Karen Young Kreeger (Ranked by scores on a survey of scholarly quality of program faculty among peers. Scores on a scale of 0 to 5*") Rank Institution Score Biochemistry and Molecular Biology 1 University of California, San Francisco 4.84 2 Massachusetts Institute of Technology 4.83 Stanford University 4.83 3 University of California, Berkeley 4.81 4 Harvard University 4.80 5 Yale University 4.59 Cell and Developmental Biology 1 Massachusetts Institute of Technology 4.86 2 Ro
Genetic Variation Illuminates Murky Human History
Douglas Steinberg | Jul 23, 2000 | 8 min read
If humans are 99.9 percent genetically identical, as President Bill Clinton is fond of asserting when he extols the Human Genome Project, that 10th-of-a-percent difference has a lot of explaining to do. How does genetic variation determine a person's unique physical traits? Can it predict someone's susceptibility to a disease? Such questions, pertaining to the present or future, are what occupy most human geneticists. A small group, however, studies genetic variation as a clue to the past. Som

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