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Pauses may help cells fine-tune gene expression.

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Clostridium botulinum produces a transcription factor that can aggregate and self-propagate a prion-like form, leading to genome-wide changes in gene expression in E. coli, according to a study.

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image: Synthetic Sensors

Synthetic Sensors

By | December 1, 2016

Engineered circuits detect endogenous transcription factors to drive cellular outputs.

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image: Infographic: How to Build a Synthetic Sensor

Infographic: How to Build a Synthetic Sensor

By | December 1, 2016

Scientists designed a genetic sensor-and-readout system, based on detecting a transcription factor, that performs a custom cellular activity.

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image: How These Rodents Got Their Stripes

How These Rodents Got Their Stripes

By | November 2, 2016

The African striped mouse and the chipmunk develop dorsal stripes through a newly identified mechanism of coat color variation.

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Researchers use the CRISPR/Cas system to express three transcription-factor genes, changing the identities of mouse cells.

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Instructor, Department of Systems Biology, University of Texas MD Anderson Cancer Center. Age: 38

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image: Adding Padding

Adding Padding

By | November 1, 2015

Adipogenesis in mice has alternating genetic requirements throughout the animals’ lives.

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image: Two Papers Pulled for Figure Fraud

Two Papers Pulled for Figure Fraud

By | August 17, 2015

A University of Florida investigation has found the lead author on both studies faked data on stress response in Caenorhabditis elegans.

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image: Toggling Between Life and Death

Toggling Between Life and Death

By | April 1, 2015

In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.

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