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image: Detecting Protein Clumps

Detecting Protein Clumps

By Ruth Williams | February 1, 2018

A synthetic genetic tool called yTRAP allows high-throughput detection of protein aggregates in cells.  

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image: Prions Found in Skin of Creutzfeldt-Jakob Patients

Prions Found in Skin of Creutzfeldt-Jakob Patients

By Jef Akst | November 24, 2017

Infectious protein aggregates from the skin of human patients can cause disease in mice.

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Clostridium botulinum produces a transcription factor that can aggregate and self-propagate a prion-like form, leading to genome-wide changes in gene expression in E. coli, according to a study.

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image: Blood Tests for Prion Disease

Blood Tests for Prion Disease

By Joshua A. Krisch | December 22, 2016

Two studies describe methods for detecting these misfolded proteins in human blood samples.

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image: Protein Folding Pioneer Dies

Protein Folding Pioneer Dies

By Kerry Grens | October 28, 2016

Susan Lindquist of MIT and the Whitehead Institute broke scientific ground on prions and heat shock proteins.

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image: Week in Review: September 5–9

Week in Review: September 5–9

By Jef Akst | September 9, 2016

Environmental magnetite in the human brain; prion structure takes shape; watching E. coli evolve in real time; learning from others’ behavior 

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image: First Glimpse at Infectious Prion Shape

First Glimpse at Infectious Prion Shape

By Abby Olena | September 8, 2016

The preliminary structure of the misfolded protein that causes mad cow disease and Creutzfeldt-Jakob disease looks like a coiled mattress spring.

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image: Prions in Plants?

Prions in Plants?

By Tanya Lewis | April 26, 2016

A plant protein that behaves like a prion when inserted into yeast could enable a form of botanical memory, a study suggests.

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image: Fearless about Folding

Fearless about Folding

By Anna Azvolinsky | January 1, 2016

Susan Lindquist has never shied away from letting her curiosity guide her research career.

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image: Esteemed Virologist Dies

Esteemed Virologist Dies

By Karen Zusi | December 7, 2015

Richard Johnson, a pioneer in research on central nervous system infections, died last month at age 84.

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