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Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read

With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.

A rendering of a human brain in blue on a dark background with blue and white lines surrounding the brain to represent the construction of new connections in the brain.

Defying Dogma: Decentralized Translation in Neurons

Danielle Gerhard, PhD | Sep 8, 2023 | 10+ min read

To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.

Illuminating Specimens Through Live Cell Imaging

Charlene Lancaster, PhD | Mar 14, 2024 | 8 min read

Live cell imaging is a powerful microscopy technique employed by scientists to monitor molecular processes and cellular behavior in real time.

The image shows many neurons in culture expressing the glutamate reporter iGluSnFR3 in green.

Biosensors Illuminate Talk Between Neurons

Mariella Bodemeier Loayza Careaga, PhD | Sep 8, 2023 | 5 min read

First developed in 2013, a fluorescent indicator has evolved to enable precise glutamate tracking.

Fluorescence microscopy imaging of astrocytes in culture, stained red

Friends and Foes: Astrocytes as Disease Targets

Deanna MacNeil, PhD | Apr 10, 2024 | 3 min read

A new platform for screening astrocyte reactivity helps researchers uncover potential therapeutic interventions to treat neurodegenerative conditions.

Researchers CHOOSE Organoids to Investigate Neurodevelopment

Deanna MacNeil, PhD | Jan 29, 2024 | 4 min read

A 3D variation of pooled CRISPR screens could connect the dots between autism spectrum disorder genetics and cell fate pathways in the developing brain.

black-and-white brain scan showing tumor

Glioblastoma Cells Imitate Immature Neurons to Invade the Brain

Sophie Fessl, PhD | Aug 5, 2022 | 3 min read

Neuron-like glioblastoma cells are the pioneers of deadly tumors’ spread through the brain, contributing to their devastating invasiveness, a study in mice finds.

Brain cell in purple on a black background. Arc mRNAs are labeled green and are mainly localized in the cell nucleus and in the dendrites.

Short-lived Molecules Support Long-term Memory

Alejandra Manjarrez, PhD | Jun 6, 2023 | 3 min read

A gene essential for information storage in the brain engages an autoregulatory feedback loop to consolidate memory.

The Brain Inside Out: Mapping the Nervous System Wiring

The Brain Inside Out: Mapping the Nervous System's Wiring

The Scientist | Jan 25, 2022 | 1 min read

An expert panel will describe their efforts to chart billions of neuronal connections and discuss how this data provides unparalleled insight into neuronal cell biology, signal processing, and behavior.

Infographic showing the selective strengthening of synapses that received stimulation.

Infographic: Synaptic Plasticity in the Sea Slug

Danielle Gerhard, PhD | Sep 8, 2023 | 1 min read

The sea slug has helped scientists in their quest to understand how neurons encode memories.

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