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tag amyloid plaques ecology neuroscience cell molecular biology

Attacking b-Amyloid at its Source
Brendan Maher | Jan 20, 2002 | 5 min read
The all-out assault to impede production of b-amyloid (Ab), the plaque-forming peptide believed by many to cause neurodegenerative Alzheimer's disease (AD), entails a war on two fronts. For those aiming to prevent plaques at their cellular source, the two clear targets are b-secretase and g-secretase, which sequentially cleave amyloid precursor protein (APP) to generate Ab. Some victories are emerging: Small molecules designed to inhibit g-secretase activity are being clinically tested, and the
Do Microbes Trigger Alzheimer’s Disease?
Jill U. Adams | Sep 1, 2017 | 10 min read
The once fringe idea is gaining traction among the scientific community.
Illustration of myelinated neuron axons in light blue, with spindly blue and purple cells interspersed among them.
A Gene Variant Linked to Alzheimer’s May Disrupt Myelin Production
Andy Carstens | Nov 22, 2022 | 5 min read
The APOE4 variant causes cholesterol buildup in the cells that make protective fatty sheaths for neurons, possibly helping explain its role in neurodegeneration.
Elusive Gamma-Secretase Identified
Nadia Halim | Jun 25, 2000 | 5 min read
Model of an inhibitor targeted to g-secretase interacting with presenilin. The background shows an Alzheimer's brain that carried a presenilin mutation, with immunohistochemistry revealing abundant amyloid plaques (red-orange patches). For years researchers have been perplexed by the identity of g-secretase, an enzyme that cuts amyloid precursor protein (APP) into amyloid ß (Aß) fragments that form telltale plaques in the brains of Alzheimer's patients. Now researchers from Merck Rese
Week in Review: May 12–16
Tracy Vence | May 16, 2014 | 3 min read
Antidepressant could prevent Alzheimer’s plaques; 12,000-year-old human skeleton sequenced; disentangling the mystery of octopus arms; taking a look at the ocular microbiome
Scanning electron micrograph (SEM) of the unicellular yeast Saccharomyces cerevisiae, known as Baker's or Brewer's yeast.
Yeast Models Provide New Insights into Neurodegenerative Diseases
Mahlon Collins | Oct 1, 2021 | 10+ min read
The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.
Brain cells with electrical firing. 3D rendering.
Microglia as Therapeutic Targets in Neurodegenerative Diseases
Sruthi S. Balakrishnan | Oct 1, 2021 | 10+ min read
Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.
Flickers of Hope
Anna Azvolinsky | Nov 1, 2017 | 8 min read
Li-Huei Tsai began her career in cancer biology, then took a fearless leap into neuroscience, making singular breakthroughs along the way.
Tiled blue-gray MRI readouts of a human brain.
Cancer Tied to Reduced Risk of Alzheimer’s Disease
Dan Robitzski | Apr 14, 2022 | 7 min read
Observational evidence for the connection is solidifying, and some clues are emerging about the mechanisms that may explain it.
white mouse on wheel
Putative Exercise Hormone Irisin Boosts Mouse Brainpower
Sophie Fessl, PhD | Sep 10, 2021 | 4 min read
Mice lacking irisin didn’t exhibit the cognition improvements that typically follow exercise, and in mouse models of Alzheimer’s disease, treatment with the hormone reduced cognitive decline.

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