The Scientist Staff | Apr 4, 1993 | 2 min read
S. Shimasaki, L. Gao, M. Shimonaka, N.Ling, "Isolation and molecular cloning of insulin-like growth factor-binding protein- 6," Molecular Endocrinology, 5:938, 1991. Shunichi Shimasaki (Whittier Institute for Diabetes and Endocrinology, La Jolla, Calif.): "There are two types of insulin-like growth factors: IGF-I and IGF-II, which act on a wide variety of target cells to regulate growth and cytodifferentiation. The IGF ligands interact with plasma membrane receptors, and the interactions are