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Researchers use the technique to turn on Oct4 or Sox2 in mouse embryonic fibroblasts and convert them into pluripotent cells. 

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image: Researchers Make Knockout Stem Cell Lines in One Step

Researchers Make Knockout Stem Cell Lines in One Step

By Ruth Williams | December 1, 2017

Combining gene editing and stem-cell induction improves efficiency of functional genetic analyses.

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The switch from maternal factors involves dynamic reprogramming of the zygotic genome.

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New technologies reveal the dynamic changes in mouse and human embryos during the first week after fertilization.

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Activating genes for reprogramming factors for a short time transforms large numbers of differentiated cells into multipotent forms that could be useful for cell-based therapies.

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image: CRISPR Used in Human Embryos to Probe Gene Function

CRISPR Used in Human Embryos to Probe Gene Function

By Ashley P. Taylor | September 20, 2017

OCT4 is necessary for blastocyst formation in the human embryo, researchers report.

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image: Stem Cells Made Waves in Biology and Medicine

Stem Cells Made Waves in Biology and Medicine

By Karen Zusi | October 1, 2016

Since their introduction to the lab, pluripotent stem cells have gone from research tool to therapeutic, but the journey has been rocky.

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image: New Stem Cell Identified

New Stem Cell Identified

By Anna Azvolinsky | May 6, 2015

Researchers isolate an easy-to-manipulate, stable, and spatially distinct pluripotent cell type.  

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image: Peer Review of STAP Work Revealed

Peer Review of STAP Work Revealed

By Kerry Grens | September 11, 2014

Early versions of two now-retracted stimulus-triggered acquisition of pluripotency studies had been rejected before.  

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image: Highly Cited Stem Cell Paper Pulled

Highly Cited Stem Cell Paper Pulled

By Kerry Grens | August 5, 2014

The authors of a 2008 Nature paper have retracted it after new data watered down the conclusions.

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