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tag bone marrow transplant cell molecular biology genetics genomics

Green and red fluorescent proteins in a zebrafish outline the animal’s vasculature in red and lymphatic system in green in a fluorescent image. Where the two overlap along the bottom of the animal is yellow.
Serendipity, Happenstance, and Luck: The Making of a Molecular Tool
Shelby Bradford, PhD | Dec 4, 2023 | 10+ min read
The common fluorescent marker GFP traveled a long road to take its popular place in molecular biology today.
Bone Marrow Makes New Fat Cells
Ashley P. Taylor | Jul 16, 2015 | 4 min read
The origins of adipocytes have been hotly debated, but a human study supports the idea that the bone marrow takes part. 
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
On the left is a normally developing mouse embryo, on the right is a slightly larger mouse embryo that also contains horse cells that glow green.
Chimera research opens new doors to understanding and treating disease
Hannah Thomasy, PhD, Drug Discovery News | Aug 9, 2023 | 10 min read
Animals with human cells could provide donor organs or help us understand neuropsychiatric disorders.
3D representation of a DNA helix and with a base offset from the main helix, illustrating the concept of base editing.
A CRISPR Alternative for Correcting Mutations That Sensitize Cells to DNA Damage
Deanna MacNeil, PhD | Oct 10, 2022 | 3 min read
Researchers turned to base editors to correct mutations causing the rare genetic disease Fanconi anemia without inducing double-strand DNA breaks.
An illustration of flowers in the shape of the female reproductive tract
Uterus Transplants Hit the Clinic
Jef Akst | Aug 1, 2021 | 10+ min read
With human research trials resulting in dozens of successful deliveries in the US and abroad, doctors move toward offering the surgery clinically, while working to learn all they can about uterine and transplant biology from the still-rare procedure.
Recoding Life
Laasya Samhita | Jan 2, 2014 | 6 min read
Rewriting the genetic code can lead to a better understanding of how living cells work, and spawn new biotechnological applications.
Sickle Cell Treatments Improve; Genetic Cure On The Horizon
Robert Finn | Feb 15, 1998 | 9 min read
WORTH WAITING FOR: Kwaku Ohene-Frempong of the Sickle Cell Disease Association of America says "gene therapy is the ultimate cure of sickle cell disease." Back in 1949, Linus Pauling determined that sickle cell disease-an inherited blood disorder that afflicts 1 in 400 African Americans-is caused by a defect in one of the genes that codes for hemoglobin. Now people with sickle cell disease are finally reaping the benefits of a half-century of research. Within the last two years, several treat
More hope for genetic fix for HIV
Jef Akst | Jun 15, 2010 | 3 min read
Genetically modifying the stem cells of HIV patients may one day prove to be an effective, one-time therapy against the hard-to-kill virus, according to the results of a proof-of-principle trial published this week in Science Translational Medicine. Human Immunodeficiency VirusImage: Wikimedia commons, NIAIDIn contrast to the widely used highly active antiretroviral therapy (HAART), which patients must continue for their entire lives to control the virus, such a genetic treatment has the potent
illustrations of cancer cells dividing in pink tones
Cancer Metastasizes Via Fusion of Tumor and Immune Cells: Study
Marcus A. Banks | Jun 17, 2021 | 3 min read
Researchers say evidence of hybridization between leukocytes and cancer indicates that this is a primary means of metastasis. Others disagree.

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