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image: Surrogate Genes Enable Reproduction

Surrogate Genes Enable Reproduction

By Jyoti Madhusoodanan | January 28, 2016

Increasing the expression of two genes from non-Y chromosomes restores spermatogenesis in male mice that lack Y chromosomes.


image: Citation Payola?

Citation Payola?

By Bob Grant | August 18, 2015

A transgenic mouse company is paying researchers who mention its animal models in scientific papers.

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image: Passenger Mutations Can Skew Results

Passenger Mutations Can Skew Results

By Kate Yandell | July 7, 2015

Some genetically engineered mice harbor unwanted mutations that hitchhike alongside desired modifications, affecting experimental outcomes.


image: Visualizing X Chromosome Inactivation

Visualizing X Chromosome Inactivation

By Abby Olena | January 21, 2014

Researchers develop mouse lines to help them see whether the maternal or paternal X chromosome is inactivated.


image: Sperm on Lockdown

Sperm on Lockdown

By Abby Olena | December 4, 2013

In a proof-of-principle study, genetic deletion of two genes renders male mice infertile by preventing sperm transport through the vas deferens.


image: More-Primitive Stem Cells Produced

More-Primitive Stem Cells Produced

By Kate Yandell | September 11, 2013

Reprogramming cells within live mice yields a new type of induced pluripotent stem cell.


image: Cranking Out New Models

Cranking Out New Models

By Kate Yandell | May 6, 2013

Scientists make mice strains with multiple mutations in less than a month without using embryonic stem cells.


image: Speaking of Science

Speaking of Science

By The Scientist Staff | May 1, 2013

May 2013's selection of notable quotes


image: Review: <em>Errors of the Human Body</em>

Review: Errors of the Human Body

By Jef Akst | April 11, 2013

This dramatic science fiction film follows a grieving father using his research to understand his infant son’s gruesome death—and explores the culture and ethics of science along the way.


image: Flickering Neurons

Flickering Neurons

By Ruth Williams | February 1, 2013

Fluorescent calcium sensors in transgenic mice give a real-time readout of neuronal activity.

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