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Pauses may help cells fine-tune gene expression.

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image: Infographic: The Various Forms of Methylated DNA

Infographic: The Various Forms of Methylated DNA

By | September 1, 2017

To expand the basic nucleotide alphabet, many species modify their DNA with epigenetic marks.

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image: The Role of DNA Base Modifications

The Role of DNA Base Modifications

By | September 1, 2017

Researchers are just beginning to scratch the surface of how several newly recognized epigenetic changes function in the genome.

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image: Nuclear Pores Come into Sharper Focus

Nuclear Pores Come into Sharper Focus

By and | December 1, 2016

Solving a long-standing structural puzzle will open the door to understanding one of the cell’s most enigmatic machines.

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Researchers use the CRISPR/Cas system to express three transcription-factor genes, changing the identities of mouse cells.

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image: Exercise Boosts Telomere Transcription

Exercise Boosts Telomere Transcription

By | July 27, 2016

Endurance exercise and metabolism are linked to transcriptional activation of human telomeres, researchers propose.

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image: Another Role for ApoE?

Another Role for ApoE?

By | January 20, 2016

Key Alzheimer’s disease–related protein may be a transcriptional regulator.

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image: Fearless about Folding

Fearless about Folding

By | January 1, 2016

Susan Lindquist has never shied away from letting her curiosity guide her research career.

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image: Shingo Kajimura: Fishing for Answers

Shingo Kajimura: Fishing for Answers

By | November 1, 2015

Assistant Professor, Department of Cell and Tissue Biology, University of California, San Francisco. Age: 39

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image: CRISPR–Enabled Epigenome Editing

CRISPR–Enabled Epigenome Editing

By | April 6, 2015

Researchers apply the genome-editing technology to alter histones at distant gene enhancers, controlling gene expression.

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