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tag noncoding dna developmental biology neuroscience evolution

Conceptual image showing molecules making up a brain shape
The Noncoding Regulators of the Brain
Christie Wilcox, PhD | Sep 12, 2022 | 10+ min read
Noncoding RNAs are proving to be critical players in the evolution of brain anatomy and cognitive complexity.
Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.
On the left is a normally developing mouse embryo, on the right is a slightly larger mouse embryo that also contains horse cells that glow green.
Chimera research opens new doors to understanding and treating disease
Hannah Thomasy, PhD, Drug Discovery News | Aug 9, 2023 | 10 min read
Animals with human cells could provide donor organs or help us understand neuropsychiatric disorders.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
First marsupial genome released
Melissa Lee Phillips | May 8, 2007 | 4 min read
Most differences between the opossom and placental mammals stem from non-coding DNA
Discovery’s Crest: A Profile of Marianne Bronner
Anna Azvolinsky | Dec 1, 2018 | 8 min read
Studying how neural crest cells journey through the embryo, this Caltech developmental biologist has revealed how they form major cell types, including peripheral neurons, bone, and smooth muscle.
Human-Specific Genes Implicated in Brain Size
Abby Olena, PhD | May 31, 2018 | 5 min read
Three members of a gene family called NOTCH2NL may have been involved in the evolution of humans’ big cortex.
New Legs to Stand On
Mary Beth Aberlin | Jun 1, 2015 | 3 min read
Reconstructing the past using ancient DNA
Conceptual image of gene expression in DNA
Enhancers: Conserved in Activity, Not in Sequence
Jack J. Lee | Nov 1, 2021 | 8 min read
Certain stretches of DNA that regulate gene expression have evolved differently from protein-coding genes.
Targeted Comparative Sequencing Illuminates Vertebrate Evolution
Ricki Lewis | Dec 8, 2002 | 6 min read
Image: Courtesy of Elliott Marguiles  PIPS ON PARADE: Researchers used a MultiPipMaker to show the alignments, expressed as percent identity plots, between a human reference sequence and several other species. This is a 20 kb region surrounding exon 2 of the MET gene. Gap-free alignable segments are represented as horizontal lines along the human reference sequence; the line's height represents the identity of that alignment. Aristotle envisioned humanity as the pinnacle of a "Great Chai

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