Microfluidic systems redefined biology by providing platforms that handle small fluid volumes, catalyzing advancements in cellular and molecular studies.

With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.

COOPERATIVE CELLS:Courtesy of Michael CarrollThe evolution of complex biologic organisms began with the symbiotic relationship between pro- and eukaryotes (I). This relationship gave rise to mitochondria (II), and the resulting diversity of unicellular organisms (III) led to their metabolic cooperativity (IV) mediated by ligand-receptor interactions and cell-cell signaling. Natural selection generated an increasing complexity (V). Failed homeostatic signaling (VI) recapitulates hylogeny/ontogeny

But, just as antibodies are finding increasing utility in cell biology, a new Food and Drug Administration classification for those products with clinical utility may affect researchers' access to the important technology (see accompanying story). Monoclonal History MAbs were born in 1975, when Georges Kohler and Cesar Milstein at the Medical Research Council Laboratories in Cambridge, England, fused two types of cells to form a hy

But, just as antibodies are finding increasing utility in cell biology, a new Food and Drug Administration classification for those products with clinical utility may affect researchers' access to the important technology (see accompanying story). Monoclonal History MAbs were born in 1975, when Georges Kohler and Cesar Milstein at the Medical Research Council Laboratories in Cambridge, England, fused two types of cells to form a hy

Editor's Note: In this essay, the authors--both scientists and writers--discuss recent news stories on evolution and express their opinions on how the stories were handled by the mainstream press. Evolution took center stage at the National Association of Biology Teachers (NABT) annual meeting in Reno, Nev., Nov. 3-8, 1998. If the teachers needed a theme, evolution was a logical choice--after all, it underlies and unifies contemporary biology. But NABT had other fish to fry. Despite a spate of c

p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.

Evidence is mounting that epigenetic marks on DNA can influence future generations in a variety of ways. But how such phenomena might affect large-scale evolutionary processes is hotly debated.

Evidence from various sciences reveals that there are diverse ways of being male, female, or both. An anthropologist argues that embracing these truths will help humans flourish.

An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.