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tag yeast two hybrid analysis developmental biology genetics genomics

Yeast Genome Doubling
Amanda B. Keener | Aug 10, 2015 | 1 min read
The results of a computational genetic analysis suggest Saccharomyces cerevisiae doubled its genome through species hybridization.
The Yeast Two-hybrid Assay
Mark Greener(mgreener@the-scientist.com) | Aug 28, 2005 | 8 min read
No protein is an island.
Two hands cut and manipulate the genome surrounded by different organs of interest.
The Cre-loxP System: A Powerful Tool in the Genetic Toolbox
Laura Tran, PhD | Dec 4, 2023 | 9 min read
Standing at the cornerstone of genetic research, Cre-loxP recombination serves as molecular scissors for precisely manipulating the genome.
Green and red fluorescent proteins in a zebrafish outline the animal’s vasculature in red and lymphatic system in green in a fluorescent image. Where the two overlap along the bottom of the animal is yellow.
Serendipity, Happenstance, and Luck: The Making of a Molecular Tool
Shelby Bradford, PhD | Dec 4, 2023 | 10+ min read
The common fluorescent marker GFP traveled a long road to take its popular place in molecular biology today.
2022 Top 10 Innovations 
2022 Top 10 Innovations
The Scientist | Dec 12, 2022 | 10+ min read
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
A Tale of Two-Hybrid
Brendan Maher | May 12, 2002 | 6 min read
Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. Courtesy of Peter UetzPeter Uetz As a graduate student, Peter Uetz investigated embryonic development in mice and chickens, working to explain how deformity relates to the protein formin. Uetz, then working at the European Molecular Biology Laboratory in Heidelberg, Germany, found few answers
a Hawaiian bobtail squid (Euprymna scolopes) resting on a reflective surface
Reshuffled Genomes May Explain Cephalopods’ Smarts
Sophie Fessl, PhD | May 13, 2022 | 4 min read
In two related studies, researchers describe huge chromosomal rearrangements and about 500 novel gene clusters in the octopus, squid, and cuttlefish genomes, which they say could help explain how they evolved their extraordinary brains.
Genetics Models Move Beyond Drosophila and the Humble Lab Mouse
Amber Dance | Sep 1, 2019 | 8 min read
Organisms with unusual genomes are helping scientists investigate gene regulation, evolution, and development.
Hybrid Animals Are Not Nature’s Misfits
Ashley Yeager | May 1, 2021 | 8 min read
In the 20th century, animals such as mules and ligers that had parents of different species were considered biological flukes, but genetic sequencing is beginning to unravel the critical role of hybridization in evolution.
Yeast Pushes the Proteomic Envelope
Mignon Fogarty | Jul 27, 2003 | 7 min read
 NETWORKED: (A) Effects of the gal4D+gal perturbation are superimposed on a gene interaction network… Click for larger version (92K) Large-scale biology once conjured images of brute-force genetic screens resulting in collections of mutants. More recently, it has meant genome sequencing on unprecedented scales. But today, as this issue's Hot Papers demonstrate, the leading edge in large-scale biology is proteomics. As in the large-scale efforts of the past, researchers rely on simp

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