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tag neurodegenerative diseases ecology disease medicine culture

Haydeh Payami is wearing a purple dress and an orange and pink scarf and standing in front of a whiteboard.
A Microbial Link to Parkinson’s Disease
Mariella Bodemeier Loayza Careaga, PhD | Dec 4, 2023 | 6 min read
Haydeh Payami helped uncover the genetic basis of Parkinson’s disease. Now, she hopes to find new ways to treat the disease by studying the gut microbiome.
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
a false color transmission electron microscope image of a neuronal cell body, with lysosomes colored dark green
Scientists Uncover Major Pathway Cells Use to Mend Leaky Lysosomes
Holly Barker, PhD | Oct 6, 2022 | 3 min read
Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say.
Gene Therapy Targets Canavan Disease
Douglas Steinberg | Sep 16, 2001 | 6 min read
The Canavan trial signals a new phase in a 10-year offensive that gene therapy researchers have waged against neurodegenerative disorders.
Understanding Huntington's Disease
Ricki Lewis | Apr 15, 2001 | 4 min read
Researchers are inching ever closer to a treatment for the inherited neurodegenerative disorder Huntington's disease (HD). Following close on the heels of recent optimistic reports on fetal cell implants1,2 comes a report from Johns Hopkins University that sheds light on a possible mechanism of neuronal destruction in HD.3 The work reveals possible new drug targets. Legendary folksinger Woody Guthrie's fight with HD brought the disease into the public eye in the 1960s. Today, some 30,000 peopl
bace1 alzheimer's disease gga3 axon neuron
Alzheimer’s-Linked Mutation Causes Blockages in Neurons
Ian Le Guillou | Nov 20, 2020 | 3 min read
The variant causes a buildup of BACE1 protein in axons in cultured neurons and mice. Researchers say it might be time to rethink failed trials that inhibit BACE1 to treat the neurodegenerative disease.
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Time Traveling Mini-Brains on a Mission to Conquer Space
Iris Kulbatski, PhD | Jun 1, 2023 | 5 min read
Alysson Muotri launched brain organoids into outer space and found that microgravity enriches our understanding of brain development and disease.
Ramified cells in a lilac background
Could Vitamin Supplementation Help Alzheimer’s Patients?
Alejandra Manjarrez, PhD | Apr 11, 2022 | 8 min read
Niacin, a form of vitamin B3 used to treat cardiovascular disease, helps immune cells in the brain fight neurodegenerative diseases such as Alzheimer’s in mice models, according to recent studies. Researchers hope that human clinical trials will swiftly follow.
Image of pancreatic organoids under a microscope with immunofluorescent staining
Pancreatic Organoids Take the Stage
Laura Tran, PhD | Dec 1, 2023 | 2 min read
Meritxell Huch tackled her pipedream of growing three-dimensional pancreatic tissue in a dish.
Best in Academia, 2012
The Scientist | Aug 1, 2012 | 1 min read
Topping this year’s survey of academic researchers is the J. David Gladstone Institutes, a San Francisco-based nonprofit biomedical research organization with a focus on cardiovascular disease, virology and immunology, and neurodegenerative disorders

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