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tag bacteriophage genetics genomics microbiology culture

bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Anti-CRISPR Protein Reduces Off-Target Effects
Diana Kwon | Jul 12, 2017 | 3 min read
AcrIIA4, an inhibitor protein from the Listeria bacteriophage, can block DNA from binding to Cas9 during genome editing.
Keeping CRISPR in Check
Anna Azvolinsky | Dec 14, 2016 | 3 min read
In bacteriophage genomes, researchers find three anti-CRISPR proteins that naturally inhibit CRISPR-Cas9 in one bacterial species and can do the same in human cells. 
Going Viral
Breeann Kirby and Jeremy J. Barr | Sep 1, 2013 | 10+ min read
From therapeutics to gene transfer, bacteriophages offer a sustainable and powerful method of controlling microbes.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Fish in a big blue aquarium
Microbes Responsible for Stealing Aquarium Medicine
Amanda Heidt | Feb 1, 2022 | 6 min read
Researchers discover that bacteria break down medicinal compounds for their nitrogen, solving a mystery that has vexed aquatic veterinarians for years.
Switch Master: A Profile of Barbara Meyer
Diana Kwon | Jan 13, 2020 | 9 min read
Working with bacteriophages and nematodes, the University of California, Berkeley, molecular biologist uncovered a role for genetic switches in early development.
Viral Soldiers
Jyoti Madhusoodanan | Jan 1, 2016 | 10+ min read
Phage therapy to combat bacterial infections is garnering attention for the second time in 100 years, but solid clinical support for its widespread use is still lacking.
Are Phages Overlooked Mediators of Health and Disease?
Catherine Offord | Feb 1, 2021 | 10+ min read
Bacteria-infecting viruses affect the composition and behavior of microbes in the mammalian gut—and perhaps influence human biology.
The Great Big Clean-Up
Kerry Grens | Sep 1, 2015 | 10+ min read
From tossing out cross-contaminated cell lines to flagging genomic misnomers, a push is on to tidy up biomedical research.

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