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tag gene variants evolution culture immunology

Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.
One Protein to Rule Them All
Shelby Bradford, PhD | Feb 28, 2024 | 10+ min read
p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.
Adeno-associated viruses
Strategies for Smuggling Gene Therapies Past the Immune System
Monique Brouillette | Jul 15, 2019 | 6 min read
Researchers are devising ways to prevent viral vectors carrying gene therapies from triggering an immune response.
Top 10 Innovations 2013
The Scientist | Dec 1, 2013 | 10+ min read
The Scientist’s annual competition uncovered a bonanza of interesting technologies that made their way onto the market and into labs this year.
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
2020 Top 10 Innovations
The Scientist | Dec 1, 2020 | 10+ min read
From a rapid molecular test for COVID-19 to tools that can characterize the antibodies produced in the plasma of patients recovering from the disease, this year’s winners reflect the research community’s shared focus in a challenging year.
tazmanian devils fighting cancer
Some Cancers Become Contagious
Katarina Zimmer | Apr 1, 2019 | 10+ min read
So far, six animal species are known to carry transmissible, “parasitic” forms of cancer, but researchers are still mystified as to how cancer can become infectious.
Macrophages Play a Double Role in Cancer
Amanda B. Keener | Apr 1, 2018 | 10+ min read
Macrophages play numerous roles within tumors, leaving cancer researchers with a choice: eliminate the cells or recruit them.
For Olfaction, a Hypothesis is Felled
Peter Mombaerts | Oct 24, 2004 | 6 min read
Peter MombaertsCourtesy of Peter MombaertsRarely do scientific studies claim that something is not the case. Rarer still do negative results appear in top-tier journals. Yet two recent papers in Nature describe what olfactory sensory neurons do not do.12The olfactory system is often compared to the immune system. The key cell types in each system, the olfactory sensory neuron (OSN) and the lymphocyte, can detect a wide variety of chemicals, both natural and synthetic. Chemical recognition by the
New Weapons Against HIV
Ricki Lewis | Oct 1, 2001 | 8 min read
As the AIDS pandemic enters its third decade, viral resistance is beginning to counter the success of "highly active antiretroviral treatment" (HAART), the multidrug cocktails introduced in 1996. "Viral resistance is a significant problem, particularly for patients who began therapy in the pre-protease inhibitor era and who developed resistance to multiple reverse transcriptase inhibitors," says Robert Schooley, a professor of infectious diseases at the University of Colorado Health Sciences Cen

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