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image: Primary Cilia in Neurons Linked to Obesity

Primary Cilia in Neurons Linked to Obesity

By Abby Olena | January 8, 2018

Three studies—one of mice and two of human genetics—describe the role of two proteins, adenylyl cyclase and melanocortin 4 receptor, in the development of obesity and diabetes. 

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image: Hormone Loss Prevents Obesity and Diabetes in Mice

Hormone Loss Prevents Obesity and Diabetes in Mice

By Abby Olena | November 6, 2017

Asprosin—involved in a rare disease called neonatal progeroid syndrome—targets neurons to stimulate appetite, and blocking the hormone wards off weight gain in rodents.

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Research in human patients and mice reveals the role of the circadian clock in the risk of heart damage at different times of day.

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image: A Molecule to Treat Obesity?

A Molecule to Treat Obesity?

By Ashley P. Taylor | October 18, 2017

GDF-15 lowers body weight in mice and primates.

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image: Skin Graft-based Gene Therapy Treats Diabetes in Mice

Skin Graft-based Gene Therapy Treats Diabetes in Mice

By Shawna Williams | August 4, 2017

A small patch of engineered cells makes an enzyme that stimulates insulin release.

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image: Study: Microglia Tied to Weight Gain in Mice

Study: Microglia Tied to Weight Gain in Mice

By Aggie Mika | July 5, 2017

Just by activating these immune cells in the brain, scientists could make mice eat more and burn fewer calories.

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image: Running on Empty

Running on Empty

By Bob Grant | June 1, 2017

Regularly taking breaks from eating—for hours or days—can trigger changes both expected, such as in metabolic dynamics and inflammation, and surprising, as in immune system function and cancer progression.

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image: Fat’s Influence on Cancer

Fat’s Influence on Cancer

By Jef Akst | April 3, 2017

Researchers at the annual American Association for Cancer Research meeting discuss the roles of adipose tissue and inflammation in the growth and spread of tumors.

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Children born to obese parents are at increased risk of failing motor development and cognitive tests, according to an NIH-led study.

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image: Why Obese Mice Prefer To Sit Around All Day

Why Obese Mice Prefer To Sit Around All Day

By Joshua A. Krisch | January 3, 2017

A study links excess body weight in the rodents with dopamine receptor inactivity and reduced movement.

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