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a microscope image of a rotifer
Bacterial Enzyme Keeps Rotifers’ Transposable Elements in Check
Christie Wilcox, PhD | Mar 3, 2022 | 5 min read
Jumping genes in bdelloid rotifers are tamped down by DNA methylation performed by an enzyme pilfered from bacteria roughly 60 million years ago, a study finds.
Outsmarting Influenza's Rapid Evolution
Philip Hunter | Jun 29, 2003 | 7 min read
Twice yearly, World Health Organization health officials meet to strategize against influenza, a malady that kills at least 250,000 people each year. In a chess match of sorts, they work to predict their opponent's next move, in this case by modifying vaccines to compensate for changes in the critical viral antigen hemagglutinin, which triggers the host's long-term immune memory. It takes several months to manufacture and distribute flu vaccines in sufficient quantities to inoculate vulnerabl
The Genetics of Society
Claire Asher and Seirian Sumner | Jan 1, 2015 | 10 min read
Researchers aim to unravel the molecular mechanisms by which a single genotype gives rise to diverse castes in eusocial organisms.
Surpassing the Law of Averages
Jeffrey M. Perkel | Sep 1, 2009 | 7 min read
By Jeffrey M. Perkel Surpassing the Law of Averages How to expose the behaviors of genes, RNA, proteins, and metabolites in single cells. By necessity or convenience, almost everything we know about biochemistry and molecular biology derives from bulk behavior: From gene regulation to Michaelis-Menten kinetics, we understand biology in terms of what the “average” cell in a population does. But, as Jonathan Weissman of the University of Califo
A Pioneer Presses Search For 'Other Side of Biology'
Gerald Edelman | Nov 13, 1988 | 4 min read
When I was a high school student, I came across Erwin Schrödingers What Is Life?. I still remember my exultant reaction—a combination of adolescent pride in feeling able to understand ideas considered beyond a young person’s means, and a genuine intellectual thrill engendered by the problems that Schrödinger addressed. Upon rereading the book, it appears to me that its major value was to provoke interest in a central problem of biology. Schrödinger’s question
Mining Bacterial Small Molecules
L. Caetano M. Antunes, Julian E. Davies and B. Brett Finlay | Jan 1, 2011 | 10 min read
As much as rainforests or deep-sea vents, the human gut holds rich stores of microbial chemicals that should be mined for their pharmacological potential.
2018 Top 10 Innovations
The Scientist | Dec 1, 2018 | 10+ min read
Biology happens on many levels, from ecosystems to electron transport chains. These tools may help spur discoveries at all of life's scales.
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Targeting Antibiotic-Resistant Bacteria with CRISPR and Phages
Anna Azvolinsky | May 18, 2015 | 3 min read
Researchers develop a CRISPR-based, two-phage system that sensitizes resistant bacteria to antibiotics and selectively kills any remaining drug-resistant bugs. 
Get the Basics
Gail Dutton | Nov 10, 2002 | 6 min read
Photo: Courtesy of Michelle Lizott Waniewski  DROP AND GIVE ME 20! Attendees at the 2002 NEB workshops labor through basic training. If you've ever been confused by the jargon of molecular biology, you are not alone. With biotechnology in the news day by day, it is easy to forget that for many of us--even for some readers of The Scientist--the tools, techniques, and concepts that undergird much of this research are foreign. To help keep up, some scientists are queuing up to learn the bas

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