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Molecular Biology
The Scientist Staff | Aug 22, 1993 | 2 min read
M. Leid, P. Kastner, R. Lyons, et al., "Purification, cloning and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently," Cell, 68:377-95, 1992. Mark Leid (Oregon State University, Corvallis): "The diverse effects of retinoic acid (RA) on development, cellular growth and differentiation, and homeostasis are mediated by two families of RA receptors that arose independently during evolution and belong to the steroid/thyroid hormone super
Molecular Biology
The Scientist Staff | Mar 1, 1992 | 2 min read
D.W. Nebert, D.R. Nelson, M.J. Coon, R.W. Estabrook, et al., "The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature," DNA and Cell Biology, 10:1-14, 1991. Daniel W. Nebert (University of Cincinnati Medical Center): "This review is the third in a series of comprehensive, up- to-date compilations of data about members of the large cytochrome P450 gene superfamily. It serves to organize a large--and growing--body of sequencing and mapping data on 154 P450 genes
MOLECULAR BIOLOGY
Paris | Jul 19, 1992 | 1 min read
Michel Philippe (Universite de Rennes, Rennes Cédex, France): "In yeast, two critical points of the cell cycle (Start and G1/S) are regulated by the same protein. This protein, called p34cdc2, is coded by the genes cdc2 in Schizzosaccharomyces pombe and CDC28 in Saccharomyces cerevisiae. By complementation of yeast mutants, proteins from higher eucaryotes homologous to cdc2 have been cloned. Moreover, p34cdc2 has been shown to be one of the main components of the well-known M-phase promotin
Collage of images including sperm, bacteria, coral, and an illustration of a researcher
Our Favorite Cell and Molecular Biology Stories of 2021
Jef Akst | Dec 2, 2021 | 3 min read
Beyond The Scientist’s coverage of COVID-19’s molecular underpinnings were many other stories highlighting the advances made in scientists’ understanding of the biology of cells.
Microfluidics: Biology’s Liquid Revolution
Laura Tran, PhD | Feb 26, 2024 | 8 min read
Microfluidic systems redefined biology by providing platforms that handle small fluid volumes, catalyzing advancements in cellular and molecular studies.
Molecular Biology-1
The Scientist Staff | Jun 23, 1991 | 1 min read
A.D. Friedman, W.H. Landschulz, S.L. McKnight, "CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells," Genes & Development, 3: 1314-22, 1989. Alan D. Friedman (Johns Hopkins Oncology Center, Baltimore): "CCAAT/enhancer binding protein (C/EBP) is perhaps best known as the prototypical basic region-leucine zipper DNA-binding protein (Science, 243:1681-88, 1989). This paper, however, represents part of the earliest efforts of the McKnight labo
Molecular Biology
The Scientist Staff | Jun 7, 1992 | 2 min read
S. Akira, T. Hirano, T. Taga, T. Kishimoto, "Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)," FASEB Journal, 4:2860-67, 1990. Shizuo Akira (Institute for Molecular and Cellular Biology, Osaka University, Japan): "Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a central role in defense mechanisms, including the immune response, acute phase reaction, and hematopoiesis. Since our success in the cloning of the IL-6 cDNA in 1985, our group has been study
Molecular Biology
The Scientist Staff | Feb 20, 1994 | 2 min read
S. Matsuda, H. Kosako, K. Takenaka, K. Moriyama, H. Sakai, T. Akiyama, Y. Gotoh, E. Nishida, "Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade," The EMBO Journal, 11:973-82, 1992. Eisuke Nishida (Department of Genetics and Molecular Biology, Institute for Virus Research, Kyoto University, Japan): "MAP kinases have been described as serine/threonine kinases that are acti
Green and red fluorescent proteins in a zebrafish outline the animal’s vasculature in red and lymphatic system in green in a fluorescent image. Where the two overlap along the bottom of the animal is yellow.
Serendipity, Happenstance, and Luck: The Making of a Molecular Tool
Shelby Bradford, PhD | Dec 4, 2023 | 10+ min read
The common fluorescent marker GFP traveled a long road to take its popular place in molecular biology today.
Microscopic image of a live amoeba.
Illuminating Specimens Through Live Cell Imaging
Charlene Lancaster, PhD | Mar 14, 2024 | 8 min read
Live cell imaging is a powerful microscopy technique employed by scientists to monitor molecular processes and cellular behavior in real time.

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