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The Cell’s Integrated Circuit: A Profile of Lucy Shapiro
Anna Azvolinsky | Aug 1, 2018 | 9 min read
Shapiro helped to found the field of systems biology.
Monoclonal Antibodies Find Utility In Cell Biology
Ricki Lewis | Dec 11, 1994 | 10+ min read
But, just as antibodies are finding increasing utility in cell biology, a new Food and Drug Administration classification for those products with clinical utility may affect researchers' access to the important technology (see accompanying story). Monoclonal History MAbs were born in 1975, when Georges Kohler and Cesar Milstein at the Medical Research Council Laboratories in Cambridge, England, fused two types of cells to form a hy
Monoclonal Antibodies Find Utility In Cell Biology
Ricki Lewis | Dec 11, 1994 | 10+ min read
But, just as antibodies are finding increasing utility in cell biology, a new Food and Drug Administration classification for those products with clinical utility may affect researchers' access to the important technology (see accompanying story). Monoclonal History MAbs were born in 1975, when Georges Kohler and Cesar Milstein at the Medical Research Council Laboratories in Cambridge, England, fused two types of cells to form a hy
How the Lysophospholipid Got its Receptor
Jerold Chun | Sep 1, 2007 | 10+ min read
How the Lysophospholipid Got its Receptor The discovery of a new family of lipid receptors provides potential targets for diseases such as multiple sclerosis and autoimmunity. By Jerold Chun Related Articles 1 By the late 1960s, researchers had become aware that this somewhat obscure class of lipids had the remarkable ability to act like an extracellular signaling molecule.2 Two prominent forms typify but do not limit lysophospholipids: lysophosphatidic acid
Frontlines
Hal Cohen | May 26, 2002 | 5 min read
Despite some success, reproductive cloning in mammals is still a tricky feat. University of Pennsylvania School of Veterinary Medicine researchers, by tracking the gene Oct4 in mice, have shown how its routine failure to reprogram after nuclear transplant commonly prevents the successful development of mammalian embryos (M. Boiani et al., "Oct4 distribution and level in mouse clones: consequences for pluripotency," Genes & Development, 6[10]:1209-19, May 15, 2002). Producing a clone requires tha
Top 10 Innovations 2012
The Scientist | Dec 1, 2012 | 10+ min read
The Scientist’s 5th installment of its annual competition attracted submissions from across the life science spectrum. Here are the best and brightest products of the year.

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