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tag chromosome folding domains neuroscience microbiology disease medicine

Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
The Genes of Parkinsonā€™s Disease
Bobby Thomas and M. Flint Beal | Feb 1, 2011 | 10 min read
The minority of Parkinson’s cases now known to have genetic origins are shedding light on the cellular mechanisms of all the rest, bringing researchers closer to a cause—and perhaps a cure.
Those We Lost in 2019
Ashley Yeager | Dec 30, 2019 | 6 min read
The scientific community said goodbye to Sydney Brenner, Paul Greengard, Patricia Bath, and a number of other leading researchers this year.
Building Nanoscale Structures with DNA
Arun Richard Chandrasekaran | Jul 16, 2017 | 10+ min read
The versatility of geometric shapes made from the nucleic acid are proving useful in a wide variety of fields from molecular computation to biology to medicine.
Antibody Alternatives
Paul Ko Ferrigno and Jane McLeod | Feb 1, 2016 | 10+ min read
Nucleic acid aptamers and protein scaffolds could change the way researchers study biological processes and treat disease.
Jumping Genes A Buyers' Guide
Hillary Sussman | Jun 15, 2003 | 6 min read
Courtesy of Ivan Rayment  CAUGHT IN MID HOP: Structure of the Tn5 transposase/DNA complex No one believed Barbara McClintock in 1951 when she first described DNA that "jumped" from site to site within maize chromosomes, altering the expression of genes near the sites of integration. In due course, these transposable elements, or transposons, were found to be ubiquitous in nature, and 30 years later McClintock won the Nobel Prize. Today transposons have gone from molecular oddity to molec
Notable
Jeffrey Perkel | Jan 20, 2002 | 3 min read
T. Sicheritz-Pontén, S.G. Andersson, "A phylogenomic approach to microbial evolution," Nucleic Acids Research, 29[2]:545-52, Jan. 15, 2001. F1000 Rating: Must Read "The paper describes methods and computer programs for automated phylogenetic analysis of complete genome datasets, as well as useful visualization tools for the results. The tools should be useful to those looking for genes that may have unusual evolutionary histories relative to other genes in the same genome." —Jonath
Top 10 Innovations 2015
The Scientist | Dec 1, 2015 | 10+ min read
The newest life-science products making waves in labs and clinics
Notebook
The Scientist Staff | Mar 15, 1998 | 7 min read
POWER EXCHANGE: Molecular biologist James Battey has become the second person to head NIDCD. SECOND GENERATION AT NIDCD Molecular biologist James F. Battey, 45, has been named the new director of the National Institute on Deafness and Other Communication Disorders (NIDCD) of the National Institutes of Health. Battey, who had been serving as acting director of NIDCD, succeeds the recently retired James B. Snow, Jr. Snow, a former University of Pennsylvania professor of otorhinolaryngology and h
One Step Beyond: Going Beyond Genomics With Proteomics And Two-Dimensional Gel Technology
Laura Defrancesco | Jan 3, 1999 | 10+ min read
Proteomes and 2D Gel Apparatus Providers Big science has moved on to proteins. With the new brand of science termed proteomics--named by the Australians Marc Wilkins and Keith Williams to mean the "set of PROTEins encoded by the genOME"--the push is on around the globe to produce a complete description of a cell/tissue/organism in terms of the proteins produced. The challenge is all the greater because the expressed protein pattern changes with time and environment--responding to developmenta

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