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tag chromosome folding domains genetics genomics microbiology disease medicine

bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Artist’s rendition of red SARS-CoV-2 coronaviruses floating near blue strands of DNA.
COVID-19 Infections May Reshape Genetic Landscape
Holly Barker, PhD | Mar 30, 2023 | 3 min read
SARS-CoV-2 infection triggers structural changes in the host cell’s DNA, which provide a molecular explanation for long COVID, a new study suggests. 
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
The cholera genome: an advance for science or for medicine?
Robert Walgate | Aug 7, 2000 | 6 min read
genome sequence will help in developing protection against the disease. Robert Walgate discovers that it might - but perhaps not in the most obvious ways.
A Genetic Checkup: Lessons from Huntington Disease and Cystic Fibrosis
Ricki Lewis | Oct 19, 2003 | 9 min read
Thom Graves Media While genome sequencing may be the new kid on the block--perhaps now with a cracking voice and fuzzy facial hair--predicting phenotypes is the stuff of classical genetics, honed on the rare single-gene disorders, such as Huntington disease (HD) and cystic fibrosis (CF), which dominated the field in the last century (see Genetic Testing Timeline). "Geneticists today are portrayed as soothsayers of the future. But predictive medicine and testing has a significant history," says
DNA Loop-the-Loops
Kate Yandell | Dec 11, 2014 | 4 min read
A new full-genome map indicates how DNA is folded within the nuclei of human cells.
Genetic Parasites and a Whole Lot More
Barry Palevitz | Oct 15, 2000 | 10+ min read
Photo: Ori Fragman, Hebrew University Hordeum spontaneum, the plant studied for BARE-1 retroelements. With genome sequences arriving almost as regularly as the morning paper, the public's attention is focused on genes--new genes to protect crops against pests; rogue genes that make bacteria resistant to antibiotics; faulty genes that, if fixed, could cure diseases such as muscular dystrophy. What many people don't realize is that genes account for only part of an organism's DNA, and in many c
Software Helps Researchers In Sorting Through The Human Genome
Ricki Lewis | Jul 21, 1996 | 10 min read
The Human Genome SIDEBAR : Selected Suppliers of Software for Gene Discovery and Analysis Genetics has been an informational science since the elucidation of DNA's structure. Today's researchers say the field shifted to a more computational mode in 1990-the year that research groups began mapping genes to specific chromosomal sites for the Human Genome Project. "That year was pivotal, because it was then that the need to sequence significant amounts of DNA became compelling," says Richard Gib
Whole-Genome SNP Genotyping
Marilee Ogren | Jun 1, 2003 | 8 min read
Clockwise from top left: images courtesy of Affymetrix, Illumina, Sequenom and Illumina Take any two individuals, sequence and compare their genomic DNA, and you'll find that the vast majority (about 99.9%) of the sequences are identical. In the remaining 0.1% lie differences in disease susceptibility, environmental response, and drug metabolism. Researchers are understandably keen to dissect these variations, most of which take the form of single-nucleotide polymorphisms (SNPs). A SNP (pron
The Genes of Parkinsonā€™s Disease
Bobby Thomas and M. Flint Beal | Feb 1, 2011 | 10 min read
The minority of Parkinson’s cases now known to have genetic origins are shedding light on the cellular mechanisms of all the rest, bringing researchers closer to a cause—and perhaps a cure.

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