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Developmental Biology
The Scientist Staff | Jan 3, 1999 | 3 min read
L.B. Zimmerman, J.M. De Jesús-Escobar, R.M. Harland, "The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4," Cell, 86:599-606, 1996. (Cited in more than 180 papers since publication) Comments by Richard M. Harland, Choh Hao Li professor of biochemistry and molecular biology, University of California, Berkeley Richard M. Harland Researchers had long suspected that the protein noggin's interaction with bone morphogenetic proteins (BMPs) dictated devel
Molecular Biology
The Scientist Staff | Feb 17, 1991 | 3 min read
R.J. Bandziulis, M.S. Swanson, G. Dreyfuss, "RNA-binding proteins as developmental regulators," Genes and Development, 3, 431-7, April 1989. Gideon Dreyfuss (University of Pennsylvania School of Medicine, Philadelphia): "Protein structural comparisons led to the discovery of identifying and unifying features shared by RNA-binding proteins of the nucleus and cytoplasm. Many of these ribonucleoproteins contain an RNA-binding domain (RBD) of approximately 90 amino acids. This amino acid sequence
Microfluidics: Biology’s Liquid Revolution
Laura Tran, PhD | Feb 26, 2024 | 8 min read
Microfluidic systems redefined biology by providing platforms that handle small fluid volumes, catalyzing advancements in cellular and molecular studies.
Developmental Biology
The Scientist Staff | Jan 3, 1999 | 3 min read
S. Piccolo, Y. Sasai, B. Lu, E.M. De Robertis, "Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4," Cell, 86:589-98, 1996. (Cited in more than 170 papers since publication) Comments by Eddy M. De Robertis, Investigator, Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles Eddy M. De Robertis In 1924, two scientists identified a small group of embryonic cells that tell their neighbor
Molecular Biology
The Scientist Staff | Feb 3, 1991 | 3 min read
T. Hai, F. Liu, W.J. Coukos, M.R. Green, "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers," Genes and Development, 3, 2083-90, December 1989. Michael R. Green (University of Massachusetts Medical Center, Worcester, Mass.): "I suspect that this paper may have attracted more than the usual attention because it is relevant to several research areas, and some of the results were unexpected. We and others had bee
One Protein to Rule Them All
Shelby Bradford, PhD | Feb 28, 2024 | 10+ min read
p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.
Molecular Biology
The Scientist Staff | Jan 19, 1992 | 1 min read
S. Ghosh, A.M. Gifford, L.R. Riviere, P. Tempst, et al., "Cloning of the p50 DNA binding subunit of NF-kB: homology to rel and dorsal," Cell, 62:1019-29, 1990. Sanker Ghosh (Yale University School of Medicine; formerly at Whitehead Institute for Biomedical Research, Cambridge, Mass.): "NF-kB is a transcription factor that is widely used for the inducible expression of a large number of cellular and viral genes. This has resulted in the study of NF-kB by researchers interested in diverse areas
Unraveling Protein-Protein Interactions
Leslie Pray | Jan 26, 2003 | 8 min read
Courtesy of Adrian Arakaki THERE'S GOLD IN THEM THERE COMPLEXES: Digging up protein-protein interactions with MULTIPROSPECTOR. Using a computer instead of a pipette, Jeffrey Skolnick contemplates the subtle forces that bring proteins together. His first computational forays helped decipher the quaternary structure of proteins--the interactions between subunits in molecules such as tropomyosin. Now Skolnick, executive director of the Buffalo Center of Excellence in Bioinformatics, Buffalo
Abstract graphene structures
Synthetic Organelles Let Researchers Control Cell Behavior
Catherine Offord | Nov 1, 2021 | 3 min read
A technique that reversibly bundles tagged cargo into artificial membraneless compartments gives scientists the ability to switch cell processes on and off.
Top 7 in developmental biology
Bob Grant | Oct 4, 2010 | 3 min read
Check out the hottest papers in developmental biology and related fields, as ranked by F1000

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