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tag sexual orientation genetics genomics immunology disease medicine developmental biology

The AIDS Research Evaluators
Lynn Gambale | Jul 9, 1995 | 6 min read
Chairman: Arnold Levine, chairman, department of molecular biology, Princeton University Barry Bloom, Weinstock Professor and Howard Hughes Medical Institute (HHMI) investigator, department of microbiology and immunology, Albert Einstein College of Medicine, New York Rebecca Buckley, professor of pediatrics and immunology, Duke University Medical Center Charles Carpenter, chairman, Office of AIDS Research Advisory Committee; professor of medicine,Brown University School of Medicine Don
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Functional Genomics Careers
Karen Young Kreeger | Jul 23, 2000 | 5 min read
Brian Zambrowicz Now that the human genome has been sequenced to a rough draft, the scientific community is looking down the road to what's next. Last month's announcement (see page 1) spotlights a nascent area of science called functional genomics. Making sense of the sequence in terms of gene function will provide research fodder--and jobs--for the years to come. "Functional genomics is everything after the sequencing studies are finished," remarks Ruben Abagyan, director of computation
The Rodent Wars: Is a Rat Just a Big Mouse?
Ricki Lewis | Jul 4, 1999 | 5 min read
Sometimes it seems as if genome projects are cropping up everywhere.1 But until costs come down, limited resources are being largely concentrated into what Joseph Nadeau, professor of genetics at Case Western Reserve University School of Medicine, calls "the genome seven," an apples-and-oranges list of viruses, bacteria, fungi, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, and mouse, with Homo sapiens in its own category.2 Researchers widely acknowledge that in the rod
2020 Top 10 Innovations
The Scientist | Dec 1, 2020 | 10+ min read
From a rapid molecular test for COVID-19 to tools that can characterize the antibodies produced in the plasma of patients recovering from the disease, this year’s winners reflect the research community’s shared focus in a challenging year.
Pushing Proteomics
Jim Kling | Apr 14, 2002 | 4 min read
Genomics is slowly but surely moving off center stage, replaced by proteomics. Though proteomics is a young field that hasn't fully found its stride, two new developments provide glimpses of the future. At the end of February, attendees of the Cambridge Healthtech Institute (CHI) Genome Tri-Conference 2002 in Santa Clara, Calif., got their first glimpse of the Protein Atlas of the Human Genome™. Developed by Abingdon, UK-based Confirmant Ltd.—a joint venture of Abingdon, UK-based Ox
Roll-Your-Own Microarrays
Jim Kling | Jan 6, 2002 | 3 min read
CDNA microarrays hold great promise for characterizing disease and performing genetic studies, but they're not exactly an out-of-the-box technology just yet. Often the scientists must prepare their own chips. Yet, this process is limited by the amount of space on the array itself—forcing researchers to make choices about which genes to include in their sample. Clinical microarray applications are further limited by the availability of sufficient cell numbers for testing purposes. Illumina
Master of the Cell
Judy Lieberman | Apr 1, 2010 | 10+ min read
By Judy Lieberman Master of the Cell RNA interference, with its powerful promise of therapy for many diseases, may also act as a master regulator of most—if not all—cellular processes. RNA silencing. Computer artwork showing a length of RNA (yellow with red rings) bound to an RNA-induced silencing complex (RISC). © Medi-Mation Ltd / Photo Researchers, Inc. ne of the biggest surprises in biology in the past d
New Era in Vaccine Development
Nadia Halim | Apr 16, 2000 | 6 min read
When all fails, try a new attack. That's exactly what researchers do when they use genome sequence data to develop vaccine candidates against the most difficult pathogenic adversaries. Recent efforts are revealing previously unknown microbial genes that may encode proteins important in triggering immunity. "Whole-genome data provides insight into all the features of [organisms] including access to virtually every single antigen that may provoke an immune response," explains Michael Gottlieb, pa
How to Create a Successful Fish Tale?
A. J. S. Rayl | Aug 19, 2001 | 10+ min read
More than 80 percent of the planet's living organisms exist only in aquatic ecosystems. Some may harbor secrets to human origins, and clues, treatments--perhaps even cures--for human disease. Some are critical bioindicators that portend the health of the biosphere. Yet, overall, scientists know little about the biochemical processes of these life forms. The vast, rich knowledge within the oceans and freshwater systems on Earth remains virtually untapped, because in the world of biological resear

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