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tag double helix developmental biology disease medicine culture

Tara Kieffer: From helix to hepatitis
Katherine Bagley | Jan 1, 2010 | 3 min read
By Katherine Bagley Tara Kieffer: From helix to hepatitis © 2009 Leah Fasten Tara Kieffer fell in love with science during a visit to her father’s biology lab at Montgomery College in Maryland. Inspired by a model of DNA’s double helix, the 5- or 6-year-old Kieffer drew a replica of the structure that has hung on her walls ever since. “DNA was beautiful and it helped spark my interest in biology,” she says. Whil
Guts and Glory
Anna Azvolinsky | Apr 1, 2016 | 9 min read
An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.
Metaphors and Dreams
Tim Radford | Jan 12, 2003 | 7 min read
The DNA revolution may be just too big to take in: beyond words, even 50 years on. Think of four chemical bases coupled exclusively to each other, adenine with thymine, guanine with cytosine, in a double helix. Then think of this double helix having the power to unwind and duplicate, to make new helixes. So far, so simple. The structure spells out a gene that makes a protein, and makes more DNA. But like the double helix itself, the challenges divide into questions of scale and complexity. In
A nude (hairless) mouse, typically used in biomedical and drug discovery research methods that rely on immunodeficient mouse strains.
Brush Up: Humanized Mice: More than the Sum of Their Parts
Deanna MacNeil, PhD | Aug 31, 2022 | 5 min read
Scientists study human health in vivo with modified mice that molecularly mimic human biology.
Macrophages Play a Double Role in Cancer
Amanda B. Keener | Apr 1, 2018 | 10+ min read
Macrophages play numerous roles within tumors, leaving cancer researchers with a choice: eliminate the cells or recruit them.
Building Nanoscale Structures with DNA
Arun Richard Chandrasekaran | Jul 16, 2017 | 10+ min read
The versatility of geometric shapes made from the nucleic acid are proving useful in a wide variety of fields from molecular computation to biology to medicine.
Methylation: Gene Expression at the Right Place and Right Time
Nadia Halim | Dec 5, 1999 | 7 min read
Courtesy of Richard Roberts, New England BiolabsModel methylation reaction: Cytosine nucleotide (red) is flipped out of the DNA double helix by a methyltransferase (white), so it can be methylated. The end product after the methyl group has been transferred to the DNA is pictured in green. A tenuous link between DNA methylation and development has existed for several years. Now findings substantiate the connection. Researchers have found the first human diseases caused by defects in the DNA meth
Can Destroying Senescent Cells Treat Age-Related Disease?
Katarina Zimmer | Mar 1, 2020 | 10+ min read
A handful of clinical trials are underway to find out whether drugs that target senescent cells can slow the ravages of old age.
Antibody Alternatives
Paul Ko Ferrigno and Jane McLeod | Feb 1, 2016 | 10+ min read
Nucleic acid aptamers and protein scaffolds could change the way researchers study biological processes and treat disease.
Science Museums Exhibit Renewed Vigor
Christine Bahls | Mar 28, 2004 | 10+ min read
Erica P. JohnsonApreschool girl with black braids presses a finger to a disk that twists a brightly lit DNA model, transforming its ladder shape into a double helix. Her head bops from side to side in wonder as the towering DNA coils and straightens. When a bigger boy claims her place, the girl joins meandering moms and dads with their charges as they twist knobs, open flaps, and simply stare at flashing helixes and orange information boards: all a part of the museum exhibit called "Genome: The

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