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tag lps receptor developmental biology cell molecular biology ecology

Monoclonal Antibodies Find Utility In Cell Biology
Ricki Lewis | Dec 11, 1994 | 10+ min read
But, just as antibodies are finding increasing utility in cell biology, a new Food and Drug Administration classification for those products with clinical utility may affect researchers' access to the important technology (see accompanying story). Monoclonal History MAbs were born in 1975, when Georges Kohler and Cesar Milstein at the Medical Research Council Laboratories in Cambridge, England, fused two types of cells to form a hy
Monoclonal Antibodies Find Utility In Cell Biology
Ricki Lewis | Dec 11, 1994 | 10+ min read
But, just as antibodies are finding increasing utility in cell biology, a new Food and Drug Administration classification for those products with clinical utility may affect researchers' access to the important technology (see accompanying story). Monoclonal History MAbs were born in 1975, when Georges Kohler and Cesar Milstein at the Medical Research Council Laboratories in Cambridge, England, fused two types of cells to form a hy
Guts and Glory
Anna Azvolinsky | Apr 1, 2016 | 9 min read
An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.
Sensory Biology Around the Animal Kingdom
The Scientist | Sep 1, 2016 | 10+ min read
From detecting gravity and the Earth’s magnetic field to feeling heat and the movement of water around them, animals can do more than just see, smell, touch, taste, and hear.
Taking Toll of Toll-Like Receptors
Karen Young Kreeger | May 4, 2003 | 7 min read
Courtesy of Alan Aderem  BAR-CODED BACTERIA: Combined activation of Toll-Like Receptors (TLRs) produces different specific responses. In this example, Microbe 1 activates TLRs 4 and 5, and is therefore likely to be a Gram-negative, flagellated bacterium. Microbe 2 activates TLR 5 and TLR 2/6, and is therefore likely to be Gram-positive and flagellated. Because of slightly different specificities, Microbe 3 would elicit a different response. Twas a head-scratcher: Twelve years ago, resear
Surpassing the Law of Averages
Jeffrey M. Perkel | Sep 1, 2009 | 7 min read
By Jeffrey M. Perkel Surpassing the Law of Averages How to expose the behaviors of genes, RNA, proteins, and metabolites in single cells. By necessity or convenience, almost everything we know about biochemistry and molecular biology derives from bulk behavior: From gene regulation to Michaelis-Menten kinetics, we understand biology in terms of what the “average” cell in a population does. But, as Jonathan Weissman of the University of Califo
Master of the Cell
Judy Lieberman | Apr 1, 2010 | 10+ min read
By Judy Lieberman Master of the Cell RNA interference, with its powerful promise of therapy for many diseases, may also act as a master regulator of most—if not all—cellular processes. RNA silencing. Computer artwork showing a length of RNA (yellow with red rings) bound to an RNA-induced silencing complex (RISC). © Medi-Mation Ltd / Photo Researchers, Inc. ne of the biggest surprises in biology in the past d
Freeze Frame
Jeffrey M. Perkel | Feb 1, 2009 | 10 min read
How to troubleshoot sample preparation for cryo-electron microscopy, an up-and-coming structural biology technique.
How Cells Find Their Way
Laura Defrancesco | Sep 2, 2001 | 5 min read
Organisms need to sense their environment. By sensing, they can develop, heal wounds, protect against invaders, and create blood vessels. Chemotaxis, or directional sensing, allows cells to detect chemicals with exquisite sensitivity. Some chemotactic cells can sense chemical gradients that differ by only a few percent from a cell's front to its back. Although discovery of the molecule types involved in chemotaxis, as with other kinds of cell signaling events, has mounted, the details of how thi
Short Shrift to Evolution?
Barry Palevitz and Ricki Lewis | Feb 1, 1999 | 7 min read
Editor's Note: In this essay, the authors--both scientists and writers--discuss recent news stories on evolution and express their opinions on how the stories were handled by the mainstream press. Evolution took center stage at the National Association of Biology Teachers (NABT) annual meeting in Reno, Nev., Nov. 3-8, 1998. If the teachers needed a theme, evolution was a logical choice--after all, it underlies and unifies contemporary biology. But NABT had other fish to fry. Despite a spate of c

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