Mark Davis | Jul 18, 2004 | 5 min read
A COMPLICATED UNION:Image redrawn from Ann Rev Biochem, 72:717–42, 2003Antigens bound by major histocompatibility complex (MHC) molecules interact with T-cell receptors (TCRs) at the heart of the interface for T-cell recognition. But, many other players are involved. Massive polyvalency within this confined space may compensate for low-affinity receptors, giving added sensitivity.In some ways, science resembles gold mining: Eager practitioners congregate around rich veins of discovery whil