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tag acute lymphoblastic leukemia ecology cell molecular biology

Leukemia and Cancer Stem Cells
Irving Weissman and Michael Clarke | Apr 1, 2006 | 4 min read
FEATUREThe Ecology of Tumors Leukemia and Cancer Stem Cells BY IRVING WEISSMAN AND MICHAEL CLARKECancers and normal tissue stem cells have much in common: Both have self-renewal capacity, and both develop into differentiated progeny. But do true cancer stem cells exist? We believe that they do and that this realization will have a major impact on the understanding and treatment of cancers. Putative cancer stem cells can be recognized by three attr
New drug target for cancer
Katherine Bagley | Nov 10, 2009 | 3 min read
Scientists have developed a new drug that blocks a transcription factor -- previously thought to be un-blockable -- that has been causally linked to leukemia and several other cancers of the lungs, ovaries, pancreas, and gastrointestinal tract, they report in linkurl:Nature;http://www.nature.com/nature/index.html this week. Bone marrow smear showing acute lymphoblastic leukemia Image: Furfur, Wikimedia Commons The Notch transcription factor regulates cell-cell communication in the Notch signal
The Makings of a Microarray Prognosis
Brendan Maher | Mar 14, 2004 | 8 min read
A TELLING EXPRESSION:© 2002 ElsevierExpression patterns for 7 and 20 genes that were selected as discriminators of relapse versus continuous complete remission (CCR) for two types of acute lymphoblastic leukemia, T-ALL and hyperdiploid >50 ALL. (from E-.J. Yeoh et al., Cancer Cell 1:133–43, 2002.)Countless things can go wrong in the complicated cell division process. Checkpoints fail, genomic instability increases, and when anarchy reigns, cancers spread. In trying to assess what is d
Cracking Down on Cancer: A Profile of Owen Witte
Diana Kwon | Apr 1, 2020 | 9 min read
Through his studies on cancer-causing viruses, the University of California, Los Angeles, professor has helped develop lifesaving treatments.
The Breakthrough Prize ?Trophy
2024 Breakthrough Prizes in Life Sciences
Danielle Gerhard, PhD | Sep 14, 2023 | 10 min read
This year’s Breakthrough Prizes honor advances in CAR T cancer therapies, cystic fibrosis, and Parkinson’s disease.
Weathering Hantavirus: Ecological Monitoring Provides Predictive Model
Steve Bunk | Jul 4, 1999 | 7 min read
Photo: Steve Bunk Dave Tinnin, field research associate in the University of New Mexico's biology department, takes blood samples and measurements of rodents caught on the research station grounds. At the end of a freeway exit near Soccoro, N.M., the hairpin turn onto a gravel road is marked by a sign that warns, "Wrong Way." But it isn't the wrong way if you want to reach the University of New Mexico's (UNM) long-term ecological research (LTER) station. The sign's subterfuge is the first indi
Genetic Screens Provide Clues About Prognosis, Risk of Second Cancer
Shawna Williams | Apr 1, 2018 | 5 min read
Mutations in the TP53 gene appear to influence the prognosis and likelihood of future cancers in pediatric leukemia patients.
DNA Chips Enlist in War on Cancer
Douglas Steinberg | Feb 20, 2000 | 10+ min read
Graphic: Cathleen Heard The boy had the classic symptoms of acute leukemia--low blood counts and tumor cells circulating in his bloodstream. But the diagnosis was tentative because the tumor cells looked atypical for leukemia. So doctors extracted RNA from the cells, made cDNAs from the RNA, and incubated the cDNAs with a chip bearing thousands of single-stranded gene fragments on its glass surface. The hybridization pattern suggested, surprisingly, that the boy had a muscle tumor. After confirm
Surpassing the Law of Averages
Jeffrey M. Perkel | Sep 1, 2009 | 7 min read
By Jeffrey M. Perkel Surpassing the Law of Averages How to expose the behaviors of genes, RNA, proteins, and metabolites in single cells. By necessity or convenience, almost everything we know about biochemistry and molecular biology derives from bulk behavior: From gene regulation to Michaelis-Menten kinetics, we understand biology in terms of what the “average” cell in a population does. But, as Jonathan Weissman of the University of Califo
Changing somatic cell function
Tudor Toma(t.toma@ic.ac.uk) | May 13, 2002 | 1 min read
Functional reprogramming of somatic cells can be achieved using a nuclear and cytoplasmic extract derived from another somatic cell type.

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